Idazoxan treatment in progressive supranuclear palsy

Details

Serval ID
serval:BIB_1C25654EF942
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Idazoxan treatment in progressive supranuclear palsy
Journal
Neurology
Author(s)
Ghika  J., Tennis  M., Hoffman  E., Schoenfeld  D., Growdon  J.
ISSN
0028-3878 (Print)
Publication state
Published
Issued date
07/1991
Volume
41
Number
7
Pages
986-91
Notes
Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jul
Abstract
To confirm the preliminary report that increases in norepinephrine neurotransmission improve motor performance, we administered the investigational drug idazoxan (IDA) to nine patients with progressive supranuclear palsy (PSP) according to a double-blind crossover protocol. There were seven women and two men, whose mean age was 70 years and mean duration of illness 4 years. All had an advanced parkinsonian syndrome, supranuclear ocular motor palsies, and poor responses to dopaminergic drugs. During administration of 40 mg tid of IDA, the total score and the motor subscale score of the United Parkinson's Disease Rating Scale significantly decreased. Features that improved most included mobility, balance, gait, and measures of digital dexterity. There were no significant changes in any measure during placebo administration. Corticobulbar manifestations and eye movements were not significantly improved during treatment. Side effects of IDA included transient hypertension, tachycardia, action tremor, flushing, and sweating, but none was so severe that any patient withdrew from the study. Among the few attempted treatments of PSP, IDA is the first medication shown in a double-blind study to improve aspects of motor function.
Keywords
Adrenergic alpha-Antagonists/therapeutic use Aged Dementia/etiology Depression/etiology Dioxanes/adverse effects/*therapeutic use Female Gait Humans Idazoxan Male Movement/drug effects Severity of Illness Index Supranuclear Palsy, Progressive/*drug therapy/physiopathology/psychology
Pubmed
Web of science
Create date
25/01/2008 11:46
Last modification date
20/08/2019 12:52
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