Maternal risk factors for the VACTERL association: A EUROCAT case-control study.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_1C0AA39DA7C4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Maternal risk factors for the VACTERL association: A EUROCAT case-control study.
Journal
Birth defects research
Author(s)
van de Putte R., van Rooij IALM, Haanappel C.P., Marcelis CLM, Brunner H.G., Addor M.C., Cavero-Carbonell C., Dias C.M., Draper E.S., Etxebarriarteun L., Gatt M., Khoshnood B., Kinsner-Ovaskainen A., Klungsoyr K., Kurinczuk J.J., Latos-Bielenska A., Luyt K., O'Mahony M.T., Miller N., Mullaney C., Nelen V., Neville A.J., Perthus I., Pierini A., Randrianaivo H., Rankin J., Rissmann A., Rouget F., Schaub B., Tucker D., Wellesley D., Wiesel A., Zymak-Zakutnia N., Loane M., Barisic I., de Walle HEK, Bergman JEH, Roeleveld N.
ISSN
2472-1727 (Electronic)
Publication state
Published
Issued date
15/05/2020
Peer-reviewed
Oui
Volume
112
Number
9
Pages
688-698
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The VACTERL association (VACTERL) is the nonrandom occurrence of at least three of these congenital anomalies: vertebral, anal, cardiac, tracheoesophageal, renal, and limb anomalies. Despite suggestions for involvement of several genes and nongenetic risk factors from small studies, the etiology of VACTERL remains largely unknown.
To identify maternal risk factors for VACTERL in offspring in a large European study.
A case-control study was performed using data from 28 EUROCAT registries over the period 1997-2015 with case and control ascertainment through hospital records, birth and death certificates, questionnaires, and/or postmortem examinations. Cases were diagnosed with VACTERL, while controls had a genetic syndrome and/or chromosomal abnormality. Data collected included type of birth defect and maternal characteristics, such as age, use of assisted reproductive techniques (ART), and chronic illnesses. Multivariable logistic regression analyses were performed to estimate confounder adjusted odds ratios (aOR) with 95% confidence intervals (95% CI).
The study population consisted of 329 VACTERL cases and 49,724 controls with recognized syndromes or chromosomal abnormality. For couples who conceived through ART, we found an increased risk of VACTERL (aOR 2.3 [95% CI 1.3, 3.9]) in offspring. Pregestational diabetes (aOR 3.1 [95% CI 1.1, 8.6]) and chronic lower obstructive pulmonary diseases (aOR 3.9 [95% CI 2.2, 6.7]) also increased the risk of having a child with VACTERL. Twin pregnancies were not associated with VACTERL (aOR 0.6 [95% CI 0.3, 1.4]).
We identified several maternal risk factors for VACTERL in offspring befitting a multifactorial etiology.
Keywords
assisted reproductive techniques, etiology, maternal factors, pregestational diabetes, respiratory disorders
Pubmed
Web of science
Open Access
Yes
Create date
25/04/2020 17:22
Last modification date
15/01/2021 7:08
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