Differences in Sampling Site on Postmortem Cerebrospinal Fluid Biochemistry: A Preliminary Study.

Details

Serval ID
serval:BIB_1BE7E20999D6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Differences in Sampling Site on Postmortem Cerebrospinal Fluid Biochemistry: A Preliminary Study.
Journal
The American journal of forensic medicine and pathology
Author(s)
Garland J., Philcox W., Kesha K., Morrow P., Lam L., Spark A., Palmiere C., Elstub H., Cala A.D., Stables S., Tse R.
ISSN
1533-404X (Electronic)
ISSN-L
0195-7910
Publication state
Published
Issued date
12/2018
Peer-reviewed
Oui
Volume
39
Number
4
Pages
304-308
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Cerebrospinal fluid (CSF) is often analyzed at postmortem. The presented preliminary study compared postmortem CSF samples for biochemical analysis from the subarachnoid space around the spinal cord and ventricular space of the brain. This study compared 15 paired CSF samples in which the CSF from the subarachnoid space via lumbar puncture had higher sodium and chloride levels and lower magnesium and potassium levels than CSF from the ventricles. The differences correlated significantly with the deceased's age and had a similar trend with postmortem interval. This study suggests that CSF from different collection sites has different electrolyte concentrations, which are age and possibly postmortem interval dependent. When collecting CSF, the pathologist should document the collection site, age, and postmortem interval, and the mixing of CSF samples from different sites should be avoided. Further studies are warranted to clarify other possible reasons to explain the observed differences.
Keywords
Adult, Age Factors, Aged, Aged, 80 and over, Cerebral Ventricles/metabolism, Chlorides/cerebrospinal fluid, Female, Forensic Pathology/methods, Humans, Magnesium/cerebrospinal fluid, Male, Middle Aged, Postmortem Changes, Potassium/cerebrospinal fluid, Sodium/cerebrospinal fluid, Spinal Cord/metabolism, Subarachnoid Space/metabolism, Young Adult
Pubmed
Web of science
Create date
24/07/2018 11:05
Last modification date
20/08/2019 12:52
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