In vivo effect of flucloxacillin in experimental endocarditis caused by mecC-positive staphylococcus aureus showing temperature-dependent susceptibility in vitro.

Details

Serval ID
serval:BIB_1BCA842865A6
Type
Article: article from journal or magazin.
Collection
Publications
Title
In vivo effect of flucloxacillin in experimental endocarditis caused by mecC-positive staphylococcus aureus showing temperature-dependent susceptibility in vitro.
Journal
Antimicrobial Agents and Chemotherapy
Author(s)
Mancini S., Laurent F., Veloso T.R., Giddey M., Vouillamoz J., Vandenesch F., Moreillon P., Entenza J.M.
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Publication state
Published
Issued date
2015
Volume
59
Number
4
Pages
2435-2438
Language
english
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) carrying the mecC gene (mecC-MRSA) exhibited at 37°C MICs of oxacillin close to those of methicillin-susceptible S. aureus (MSSA). We investigated whether at this temperature, mecC-MRSA strains respond to flucloxacillin treatment like MSSA strains, using a rat model of endocarditis. Flucloxacillin (human-like kinetics of 2 g intravenously every 6 h) cured 80 to 100% of aortic vegetations infected with five different mecC-MRSA strains. These results suggest that mecC-MRSA infections may successfully respond to treatment with β-lactams.
Pubmed
Web of science
Open Access
Yes
Create date
05/02/2015 14:25
Last modification date
20/08/2019 12:52
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