APRIL, a new member of the tumor necrosis factor family, modulates death ligand-induced apoptosis

Details

Serval ID
serval:BIB_1B8C1CCECC77
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
APRIL, a new member of the tumor necrosis factor family, modulates death ligand-induced apoptosis
Journal
Cell Death and Differentiation
Author(s)
Roth  W., Wagenknecht  B., Klumpp  A., Naumann  U., Hahne  M., Tschopp  J., Weller  M.
ISSN
1350-9047 (Print)
Publication state
Published
Issued date
04/2001
Volume
8
Number
4
Pages
403-10
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr
Abstract
APRIL (a proliferation-inducing ligand) is a newly identified member of the tumor necrosis factor (TNF) family. Tumor growth-promoting as well as apoptosis-inducing effects of APRIL have been described. Here, we report that five of 12 human malignant glioma cell lines express APRIL. APRIL gene transfer experiments revealed that malignant glioma cells are refractory to growth-promoting activity of APRIL in vitro and in vivo. Interestingly, ectopic expression of APRIL confers minor protection from apoptotic cell death induced by the death ligands, CD95 ligand (CD95L) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo2 ligand (Apo2L). This antiapoptotic activity is specific for death ligand/receptor-mediated apoptosis since APRIL does not protect glioma cells from the cytotoxicity of the drugs, teniposide, vincristine, lomustine or cisplatin. Ectopic expression of APRIL is associated with the upregulation of X-linked inhibitor of apoptosis protein (XIAP), providing a possible explanation for the antiapoptotic activity observed here. In contrast, APRIL does not regulate the expression levels of the antiapoptotic proteins FLICE-inhibitory protein (FLIP), Bcl-2 or Bcl-X(L). These findings suggest that APRIL is involved in the regulation of death ligand-induced apoptotic signaling in malignant glioma cells.
Keywords
Animals Antigens, CD95/*pharmacology *Apoptosis Apoptosis Regulatory Proteins Cell Division Glioma/genetics/metabolism/*pathology Humans Membrane Glycoproteins/*pharmacology Membrane Proteins/genetics/*physiology Mice Mice, Nude Protein Biosynthesis *Proteins RNA, Neoplasm/biosynthesis TNF-Related Apoptosis-Inducing Ligand Transfection Tumor Cells, Cultured Tumor Necrosis Factor Ligand Superfamily Member 13 Tumor Necrosis Factor-alpha/genetics/*pharmacology/*physiology Up-Regulation X-Linked Inhibitor of Apoptosis Protein
Pubmed
Web of science
Create date
24/01/2008 15:19
Last modification date
20/08/2019 12:52
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