Restricted expression of the erythroid/brain glucose transporter isoform to perivenous hepatocytes in rats. Modulation by glucose.

Details

Serval ID
serval:BIB_1B3F4E53476A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Restricted expression of the erythroid/brain glucose transporter isoform to perivenous hepatocytes in rats. Modulation by glucose.
Journal
Journal of Clinical Investigation
Author(s)
Tal M., Schneider D.L., Thorens B., Lodish H.F.
ISSN
0021-9738
Publication state
Published
Issued date
09/1990
Peer-reviewed
Oui
Volume
86
Number
3
Pages
986-992
Language
english
Abstract
The "erythroid/brain" glucose transporter (GT) isoform is expressed only in a subset of hepatocytes, those forming the first row around the terminal hepatic venules, while the "liver" GT is expressed in all hepatocytes. After 3 d of starvation, a three- to fourfold elevation of expression of the erythroid/brain GT mRNA and protein is detected in the liver as a whole; this correlates with the expression of this GT in more hepatocytes, those forming the first three to four rows around the hepatic venules. Starvation-dependent expression of the erythroid/brain GT on the plasma membrane of these additional hepatocytes is lost within 3 h of glucose refeeding; however, by immunoblotting we show that the protein is still present. Its loss from the surface is possibly explained by internalization.
Keywords
Animals, Blotting, Northern, Blotting, Western, Cell Membrane, Fluorescent Antibody Technique, Gene Expression, Glucose, Liver, Monosaccharide Transport Proteins, RNA, Messenger, Rats, Rats, Inbred Strains, Starvation, Time Factors, Tissue Distribution
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 13:41
Last modification date
20/08/2019 12:52
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