Regional therapy of melanoma

Details

Serval ID
serval:BIB_1B1C5AF01BC4
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Regional therapy of melanoma
Journal
European Journal of Cancer
Author(s)
Lejeune  F. J., Lienard  D., Leyvraz  S., Mirimanoff  R. O.
ISSN
0959-8049 (Print)
Publication state
Published
Issued date
1993
Volume
29A
Number
4
Pages
606-12
Notes
Journal Article
Review
Abstract
Little progress has been made in the systemic treatment of melanoma, that is for disseminated stage IV disease. However, the tumour resistance to therapy, especially chemotherapy can be overcome in melanoma by high doses of anticancer agents administered regionally. The purpose of this paper is to illustrate this concept by two modes of regional treatment namely: (1) isolation perfusion of the limbs with high doses of cytokines and chemotherapy under hyperthermia and (2) local treatment of metastatic melanoma. The third part will be devoted to the role of another regional treatment, radiotherapy, where the association with hyperthermy also looks promising.
Keywords
Adult Aged Aged, 80 and over Antineoplastic Agents/*administration & dosage/adverse effects Chemotherapy, Cancer, Regional Perfusion Feasibility Studies Female Humans Interferon-gamma, Recombinant/administration & dosage/adverse effects Male Melanoma/radiotherapy/*therapy Melphalan/administration & dosage/adverse effects Middle Aged Tumor Necrosis Factor-alpha/administration & dosage/adverse effects
Pubmed
Web of science
Create date
28/01/2008 8:32
Last modification date
20/08/2019 12:51
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