Corneal stromal demarcation line determined with anterior segment optical coherence tomography following a very high intensity corneal collagen cross-linking protocol.

Details

Serval ID
serval:BIB_1AF87269FE87
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Corneal stromal demarcation line determined with anterior segment optical coherence tomography following a very high intensity corneal collagen cross-linking protocol.
Journal
Cornea
Author(s)
Kymionis G.D., Tsoulnaras K.I., Liakopoulos D.A., Grentzelos M.A., Paraskevopoulos T.A., Zacharioudaki M.E., Zivkovic M., Kouroupaki A.I., Tsilimbaris M.K.
ISSN
1536-4798 (Electronic)
ISSN-L
0277-3740
Publication state
Published
Issued date
06/2015
Peer-reviewed
Oui
Volume
34
Number
6
Pages
664-667
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
To evaluate corneal stromal demarcation line depth after very high intensity (18 mW/cm) ultraviolet-A irradiation for a 5-minute corneal collagen cross-linking (CXL) protocol with the use of anterior segment optical coherence tomography.
This prospective interventional study enrolled 14 patients (18 eyes) with progressive keratoconus who underwent CXL with an ultraviolet-A irradiation intensity of 18 mW/cm for 5 minutes. One month postoperatively, corneal stromal demarcation line depth was measured with the use of anterior segment optical coherence tomography by 2 independent observers. The rate of reepithelialization and endothelial cell density at a 3-month follow-up period were also evaluated.
No intraoperative or postoperative complications were observed in any of the patients. No statistically significant difference between the 2 observers' measurements was observed (P = 0.989). Mean corneal stromal demarcation line depth was 223 ± 32 μm (range, 159-265 μm). The mean endothelial cell density decreased from 2714 ± 174 preoperatively to 2671 ± 192 at 3 months postoperatively; however, this decrease was not statistically significant (P = 0.221).
Corneal stromal demarcation line depth after a very high intensity 5-minute CXL protocol seems to be shallower than the standard Dresden protocol.
Keywords
Adult, Cell Count, Collagen/metabolism, Corneal Endothelial Cell Loss/diagnosis, Corneal Stroma/metabolism, Corneal Stroma/pathology, Corneal Topography, Cross-Linking Reagents, Endothelium, Corneal/pathology, Female, Follow-Up Studies, Humans, Keratoconus/drug therapy, Keratoconus/metabolism, Male, Photochemotherapy, Photosensitizing Agents/therapeutic use, Prospective Studies, Riboflavin/therapeutic use, Tomography, Optical Coherence/methods, Ultraviolet Rays, Young Adult
Pubmed
Web of science
Create date
30/09/2019 16:05
Last modification date
06/10/2019 5:26
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