Inhibition of antigen-induced T-cell clone proliferation by antigen-specific antibodies.

Details

Serval ID
serval:BIB_1AEF1412ADCB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Inhibition of antigen-induced T-cell clone proliferation by antigen-specific antibodies.
Journal
Nature
Author(s)
Corradin G., Engers H.D.
ISSN
0028-0836 (Print)
ISSN-L
0028-0836
Publication state
Published
Issued date
1984
Volume
308
Number
5959
Pages
547-548
Language
english
Abstract
Attempts to inhibit the recognition of soluble antigens by T lymphocytes using antibodies specific for the antigen in question have been uniformally unsuccessful, in contrast to the observed specific inhibition of antibody generation by B cells. One exception is the unique situation whereby anti-hapten antisera inhibit the T-cell proliferative responses observed when hapten-specific T lymphocytes or clones are cultured with hapten-derivatized cells or proteins. The inability to inhibit T-cell functions by antigen-specific antibodies has been interpreted in several ways: (1) T cells possess a different repertoire from B cells; (2) the antibodies tested recognize epitopes present on the native antigen, whereas T cells recognize non-native (processed) structures; (3) the antigenic determinant(s) recognized by T cells on the surface of antigen presenting cells are either not accessible to antibodies, or are present in low amounts. The development of antigen-specific T-cell clones and monoclonal antibodies both specific for the same antigenic determinants now allows this question to be investigated definitively. Here, we report for the first time the specific inhibition of antigen-induced T-cell clone proliferation by a monoclonal antibody directed against the relevant soluble protein antigen.
Keywords
Animals, Antibodies, Monoclonal, Antigen-Antibody Complex, Apoproteins/immunology, Cattle, Clone Cells, Cytochrome c Group/immunology, Cytochromes c, Lymphocyte Activation, Mice, Mice, Inbred BALB C, Spleen/immunology, T-Lymphocytes/immunology
Pubmed
Web of science
Create date
24/01/2008 14:55
Last modification date
20/08/2019 12:51
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