Prise en charge des troubles salivaires dans la sclérose latérale amyotrophique [Salivary management in amyotrophic lateral sclerosis]

Details

Serval ID
serval:BIB_1AC528C4BB77
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Prise en charge des troubles salivaires dans la sclérose latérale amyotrophique [Salivary management in amyotrophic lateral sclerosis]
Journal
Revue medicale suisse
Author(s)
Fries S., Schweizer V.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
03/10/2018
Peer-reviewed
Oui
Volume
14
Number
621
Pages
1758-1762
Language
french
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
80 % of patients suffering from amyotrophic lateral sclerosis present bulbar involvement and 50 % have salivary symptoms, which are often poorly managed. They present either with drooling or thick secretions. This elevates the risk of bronchoaspiration leading to pneumonia, second cause of death in this population. It is hence paramount to treat, while enhancing the patient's quality of life. The first line of treatment is a salivary drying agent such as an atropine-based medication. These treatments have a low adverse effect rate, are reversible and easy to dose. Management of thick secretions is possible with mucolytics. Taking into account the severity of the bulbar involvement, the second line of treatment, once controversial, is salivary gland injections of botulinium toxin.
Keywords
Amyotrophic Lateral Sclerosis/complications, Humans, Quality of Life, Salivary Glands/physiopathology, Sialorrhea/etiology, Sialorrhea/therapy
Pubmed
Create date
17/10/2018 10:45
Last modification date
20/08/2019 12:51
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