Grands défects chondraux et ostéochondraux du genou : traitement par greffe chondrocytaire autologue [Treatment of extensive chondral and osteochondral knee defects with autologous chondrocytes implantation]

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State: Public
Version: Final published version
License: All rights reserved
Serval ID
serval:BIB_1A99A6372E2B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Grands défects chondraux et ostéochondraux du genou : traitement par greffe chondrocytaire autologue [Treatment of extensive chondral and osteochondral knee defects with autologous chondrocytes implantation]
Journal
Revue Médicale Suisse
Author(s)
Martin R., Laurent A., Applegate L.A., Philippe V.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
14/12/2022
Peer-reviewed
Oui
Volume
18
Number
808
Pages
2384-2390
Language
french
Notes
Publication types: English Abstract ; Journal Article
Publication Status: ppublish
Abstract
Treatment of extensive chondral and osteochondral defects in the knee remains a challenge. The traditional bone marrow stimulation and osteochondral mosaicplasty are effective but this is indicated only for lesions smaller than 4 cm <sup>2</sup> . In addition, while they are offered in young patients, functional deterioration is often observed after 2 years. In contrast, Autologous Chondrocyte Implantation (ACI) has proven to be efficient and durable even in larger lesions. These factors have encouraged our team to consider ACI as a valuable tool, but it was not readily available in Switzerland. In this article, we describe why and how we have developed and refined the technique in our University Hospital for the clinical implementation of this cell-based therapy, performed under a quality assurance system and following good manufacturing practices.
Keywords
Humans, Chondrocytes, Cartilage, Articular/surgery, Transplantation, Autologous, Knee Joint/surgery, Knee Joint/pathology, Knee Injuries/surgery
Pubmed
Create date
15/12/2022 15:30
Last modification date
18/09/2023 5:57
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