Genotype-covariate interaction effects and the heritability of adult body mass index.

Details

Serval ID
serval:BIB_1A663429E340
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genotype-covariate interaction effects and the heritability of adult body mass index.
Journal
Nature Genetics
Author(s)
Robinson M.R., English G., Moser G., Lloyd-Jones L.R., Triplett M.A., Zhu Z., Nolte I.M., van Vliet-Ostaptchouk J.V., Snieder H., Esko T., Milani L., Mägi R., Metspalu A., Magnusson PKE, Pedersen N.L., Ingelsson E., Johannesson M., Yang J., Cesarini D., Visscher P.M.
Working group(s)
LifeLines Cohort Study
ISSN
1546-1718 (Electronic)
ISSN-L
1061-4036
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
49
Number
8
Pages
1174-1181
Language
english
Abstract
Obesity is a worldwide epidemic, with major health and economic costs. Here we estimate heritability for body mass index (BMI) in 172,000 sibling pairs and 150,832 unrelated individuals and explore the contribution of genotype-covariate interaction effects at common SNP loci. We find evidence for genotype-age interaction (likelihood ratio test (LRT) = 73.58, degrees of freedom (df) = 1, P = 4.83 × 10-18), which contributed 8.1% (1.4% s.e.) to BMI variation. Across eight self-reported lifestyle factors, including diet and exercise, we find genotype-environment interaction only for smoking behavior (LRT = 19.70, P = 5.03 × 10-5 and LRT = 30.80, P = 1.42 × 10-8), which contributed 4.0% (0.8% s.e.) to BMI variation. Bayesian association analysis suggests that BMI is highly polygenic, with 75% of the SNP heritability attributable to loci that each explain <0.01% of the phenotypic variance. Our findings imply that substantially larger sample sizes across ages and lifestyles are required to understand the full genetic architecture of BMI.

Keywords
Adolescent, Adult, Aged, Aging/genetics, Bayes Theorem, Body Mass Index, Female, Gene-Environment Interaction, Genotype, Humans, Life Style, Male, Middle Aged, Multifactorial Inheritance, Obesity/genetics, Polymorphism, Single Nucleotide, Sex Characteristics, Twins/genetics, Young Adult
Pubmed
Web of science
Create date
03/08/2017 14:24
Last modification date
20/08/2019 12:51
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