Funding characteristics of randomised clinical trials supported by the Swiss National Science Foundation: a retrospective cohort study.

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State: Public
Version: Final published version
Serval ID
serval:BIB_1A190B3DDE8E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Funding characteristics of randomised clinical trials supported by the Swiss National Science Foundation: a retrospective cohort study.
Journal
Swiss medical weekly
Author(s)
Amstutz A., Schandelmaier S., Frei R., Surina J., Agarwal A., Alturki R., von Niederhäusern B., von Elm E., Briel M.
Working group(s)
On Behalf Of The MAking Randomized Trials Affordable Marta Group
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
148
Pages
w14587
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Failure to publish publicly funded research represents a waste of scarce research resources across medical disciplines and countries. In Switzerland, about 40% of randomised clinical trials (RCTs) supported by the Swiss National Science Foundation (SNSF) were not published. We aimed to describe funding characteristics of published and unpublished RCTs supported by the SNSF, to quantify the amount of money spent for unpublished studies, and to compare our results to a similar study performed in the UK.
We established a retrospective cohort of RCTs funded by the SNSF up to 2015. For each RCT proposal, two investigators independently identified corresponding publications in electronic databases and trial registries. Teams of two investigators independently extracted details from the original SNSF proposal and, if available, from trial registries or publications. In addition, we surveyed principal investigators about trial costs and additional sources of funding.
We included 101 RCTs supported by the SNSF between 1986 and 2015. Most were single-centre RCTs with a median of 138 participants (interquartile range [IQR] 76-400). Overall, 67 (67%) principal investigators responded to our main survey questions. Median total costs per RCT were CHF 428 000 (IQR 282 000-900 000) of which the SNSF provided a median CHF 222 000 (67% of total costs, IQR 40-80%). Most investigators (70%) mentioned additional funding, mainly from their own institution or private foundations. A total of CHF 6.7 million was granted to RCTs that remained unpublished. Funding characteristics were similar to publicly funded trials in the UK.
A third of the total SNSF grant sum spent on healthcare RCTs between 1986 and 2015 did not result in peer-reviewed scientific publications. New SNSF grant schemes might improve publication outcomes but their effectiveness needs to be evaluated.
Keywords
Cost-Benefit Analysis, Financing, Organized/economics, Humans, Publishing, Randomized Controlled Trials as Topic, Retrospective Studies, Switzerland
Pubmed
Web of science
Open Access
Yes
Create date
01/02/2018 19:35
Last modification date
20/08/2019 13:51
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