Association between protective efficacy of anti-lipopolysaccharide (LPS) antibodies and suppression of LPS-induced tumor necrosis factor alpha and interleukin 6. Comparison of O side chain-specific antibodies with core LPS antibodies.

Details

Serval ID
serval:BIB_1A01B79753D7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Association between protective efficacy of anti-lipopolysaccharide (LPS) antibodies and suppression of LPS-induced tumor necrosis factor alpha and interleukin 6. Comparison of O side chain-specific antibodies with core LPS antibodies.
Journal
The Journal of experimental medicine
Author(s)
Baumgartner J.D., Heumann D., Gerain J., Weinbreck P., Grau G.E., Glauser M.P.
ISSN
0022-1007
ISSN-L
0022-1007
Publication state
Published
Issued date
01/03/1990
Peer-reviewed
Oui
Volume
171
Number
3
Pages
889-896
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Two-core LPS antibodies, the rabbit J5 polyclonal antiserum and the human anti-lipid A IgM mAb HA-1A, did not improve the survival of mice challenged with E. coli O111 or P. aeruginosa 3, or with the LPS extracted from them, and did not decrease the incidence of Shwartzman reactions in rabbits challenged with O111 LPS. In contrast, O side chain-specific rabbit antisera were protective in these models. The protection afforded by O side chain-specific antisera against endotoxin lethality was associated with decreased LPS-induced serum TNF and IL-6 levels, whereas core LPS antibodies had no effect on TNF or IL-6 levels. The absence of reduction of LPS-induced cytokines levels by core LPS antibodies suggests that these antibodies are not able to prevent the interactions between LPS and target cells.
Keywords
Animals, Antibodies, Bacterial/immunology, Female, Interleukin-6/biosynthesis, Lethal Dose 50, Lipopolysaccharides/immunology, Lipopolysaccharides/toxicity, Mice, Mice, Inbred C57BL, Peritonitis/prevention & control, Rabbits, Shwartzman Phenomenon, Tumor Necrosis Factor-alpha/biosynthesis
Pubmed
Web of science
Open Access
Yes
Create date
19/01/2008 19:12
Last modification date
03/07/2024 6:59
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