Rhumatologie. Autoimmunité induite par des checkpoints – naissance d’une nouvelle maladie [Rheumatology. Checkpoint-induced autoimmunity - birth of a new disease]

Details

Serval ID
serval:BIB_19E86A0612FA
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Rhumatologie. Autoimmunité induite par des checkpoints – naissance d’une nouvelle maladie [Rheumatology. Checkpoint-induced autoimmunity - birth of a new disease]
Journal
Revue medicale suisse
Author(s)
Dan D., Tapparel L., Hügle T.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
10/01/2018
Peer-reviewed
Oui
Volume
14
Number
588-589
Pages
93-96
Language
french
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Tumor cells express checkpoint proteins in order to prevent an immune reaction by T-cells. Checkpoint inhibitors are successfully used in oncology to unleash a cytotoxic immune response. Unfortunately this treatment increasingly leads to immune-related adverse events which resemble various primary autoimmune disorders known in rheumatology. Potentially, checkpoint dysfunction also underlies rheumatic diseases which would open the way for new treatment options to restore immune tolerance.
Keywords
Autoimmune Diseases/genetics, Autoimmunity, Humans, Rheumatic Diseases/genetics, Rheumatology/trends
Pubmed
Create date
25/01/2018 21:29
Last modification date
04/02/2020 8:48
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