The Role of Lipid Metabolism for Neural Stem Cell Regulation

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_19DD0D2692AB
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
The Role of Lipid Metabolism for Neural Stem Cell Regulation
Journal
Brain Plasticity
Author(s)
Knobloch M.
ISSN
2213-6312
ISSN-L
2213-6304
Publication state
Published
Issued date
2017
Volume
3
Number
1
Pages
61-71
Language
english
Abstract
Neural stem/progenitor cells (NSPCs) give rise to billions of cells during development and are critical for proper brain formation. The finding that NSPCs persist throughout adulthood has challenged the view that the brain has poor regenerative abilities and raised hope for stem cell-based regenerative therapies. For decades there has been a strong movement towards understanding the requirements of NSPCs and their regulation, resulting in the discovery of many transcription factors and signaling pathways that can influence NSPC behavior and neurogenesis. However, the role of metabolism for NSPC regulation has only gained attention recently. Lipid metabolism in particular has been shown to influence proliferation and neurogenesis, offering exciting new possible mechanisms of NSPC regulation, as lipids are not only the building blocks of membranes, but can also act as alternative energy sources and signaling entities. Here I review the recent literature examining the role of lipid metabolism for NSPC regulation and neurogenesis.
Keywords
Neurogenesis, neural stem cells, lipid metabolism, lipogenesis, fatty acid oxidation, essential fatty acids, dietary lipids, fatty acid-binding proteins
Open Access
Yes
Create date
11/12/2017 17:00
Last modification date
20/08/2019 13:50
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