Possible synergism of physical exercise and ghrelin-agonists in patients with cachexia associated with chronic heart failure.

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State: Public
Version: Final published version
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Serval ID
serval:BIB_19C8C195CCE1
Type
Article: article from journal or magazin.
Collection
Publications
Title
Possible synergism of physical exercise and ghrelin-agonists in patients with cachexia associated with chronic heart failure.
Journal
Aging Clinical and Experimental Research
Author(s)
Invernizzi M., Carda S., Cisari C.
Working group(s)
on behalf of Società Italiana per lo Studio della Sarcopenia e della Disabilità Muscolo-Scheletrica (SISDIM)
ISSN
1720-8319 (Electronic)
ISSN-L
1594-0667
Publication state
Published
Issued date
12/2013
Peer-reviewed
Oui
Language
english
Notes
Publication types: JOURNAL ARTICLE Publication Status: aheadofprint
Abstract
The occurrence of cachexia of multifactorial etiology in chronic heart failure (CHF) is a common and underestimated condition that usually leads to poor outcome and low survival rates, with high direct and indirect costs for the Health Care System. Recently, a consensus definition on cachexia has been reached, leading to a growing interest by the scientific community in this condition, which characterizes the last phase of many chronic diseases (i.e., cancer, acquired immunodeficiency syndrome). The etiology of cachexia is multifactorial and the underlying pathophysiological mechanisms are essentially the following: anorexia and malnourishment; immune overactivity and systemic inflammation; and endocrine disorders (anabolic/catabolic imbalance and resistance to growth hormone). In this paper, we review the main pathophysiological mechanisms underlying CHF cachexia, focusing also on the broad spectrum of actions of ghrelin and ghrelin agonists, and their possible use in combination with physical exercise to contrast CHF cachexia.
Pubmed
Create date
26/12/2013 17:49
Last modification date
15/07/2020 6:26
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