A prospective hospital-based study of the clinical impact of non-severe acute respiratory syndrome (Non-SARS)-related human coronavirus infection.

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Serval ID
serval:BIB_19B3E0EEBDE7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A prospective hospital-based study of the clinical impact of non-severe acute respiratory syndrome (Non-SARS)-related human coronavirus infection.
Journal
Clinical Infectious Diseases
Author(s)
Garbino J., Crespo S., Aubert J.D., Rochat T., Ninet B., Deffernez C., Wunderli W., Pache J.C., Soccal P.M., Kaiser L.
ISSN
1537-6591[electronic]
Publication state
Published
Issued date
2006
Volume
43
Number
8
Pages
1009-1015
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
BACKGROUND: In addition to the human coronaviruses (HCoVs) OC43 and 229E, which have been known for decades to cause infection in humans, 2 new members of this genus have recently been identified: HCoVs NL63 and HKU1. Their impact as a cause of respiratory tract disease in adults at risk for complications needs to be established. METHODS: We prospectively assessed the clinical impact of coronavirus infection (excluding cases of severe acute respiratory syndrome) among hospitalized adults. All patients with respiratory disease for whom bronchoalveolar lavage was performed were screened by reverse-transcriptase polymerase chain reaction for the presence of all 4 HCoVs. RESULTS: HCoV was identified in 29 (5.4%) of 540 bronchoalveolar lavage fluid specimens from 279 subjects (mean age, 51 years; 63% male). HCoV OC43 was identified most frequently (12 isolates), followed by 229E (7 isolates), NL63 (6 isolates), and HKU1 (4 isolates). In all, 372 (69%) of 540 bronchoalveolar lavage fluid specimens were negative for bacteria, and 2 persons were coinfected with other respiratory viruses. Transplantation was the most common underlying condition. Of the 29 patients who had HCoV identified in their bronchoalveolar lavage fluid specimens, 9 (31%) were hospitalized in the intensive care unit, 22 (76%) presented to the hospital with acute respiratory symptoms, 16 (55%) presented with cough and/or sputum, 13 (45%) presented with dyspnea, 16 (55%) had experienced prior respiratory infection, and 18 (62%) had a new infiltrate that was visible on chest radiograph. The most frequent final diagnosis was a lower respiratory tract infection. CONCLUSIONS: The recently discovered HCoVs NL63 and HKU1 contribute significantly to the overall spectrum of coronavirus infection. Our study also suggests that coronaviruses contribute to respiratory symptoms in most cases.
Keywords
Adolescent, Adult, Aged, Bronchoalveolar Lavage Fluid, Coronavirus, Coronavirus 229E, Human, Coronavirus Infections, Coronavirus OC43, Human, Female, Humans, Lung Diseases, Lung Transplantation, Male, Middle Aged, Prospective Studies, Switzerland
Pubmed
Web of science
Open Access
Yes
Create date
21/01/2008 13:54
Last modification date
25/09/2019 7:08
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