Best Practice Recommendations for the Diagnosis and Management of Children With Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2 (PIMS-TS; Multisystem Inflammatory Syndrome in Children, MIS-C) in Switzerland.

Details

Serval ID
serval:BIB_19A74F059366
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Best Practice Recommendations for the Diagnosis and Management of Children With Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2 (PIMS-TS; Multisystem Inflammatory Syndrome in Children, MIS-C) in Switzerland.
Journal
Frontiers in pediatrics
Author(s)
Schlapbach L.J., Andre M.C., Grazioli S., Schöbi N., Ritz N., Aebi C., Agyeman P., Albisetti M., Bailey DGN, Berger C., Blanchard-Rohner G., Bressieux-Degueldre S., Hofer M., L'Huillier A.G., Marston M., Meyer Sauteur P.M., Pachlopnik Schmid J., Perez M.H., Rogdo B., Trück J., Woerner A., Wütz D., Zimmermann P., Levin M., Whittaker E., Rimensberger P.C.
Working group(s)
PIMS-TS working group of the Interest Group for Pediatric Neonatal Intensive Care (IGPNI) of the Swiss Society of Intensive Care and the Pediatric Infectious Diseases Group Switzerland (PIGS)
ISSN
2296-2360 (Print)
ISSN-L
2296-2360
Publication state
Published
Issued date
2021
Peer-reviewed
Oui
Volume
9
Pages
667507
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Background: Following the spread of the coronavirus disease 2019 (COVID-19) pandemic a new disease entity emerged, defined as Pediatric Inflammatory Multisystem Syndrome temporally associated with COVID-19 (PIMS-TS), or Multisystem Inflammatory Syndrome in Children (MIS-C). In the absence of trials, evidence for treatment remains scarce. Purpose: To develop best practice recommendations for the diagnosis and treatment of children with PIMS-TS in Switzerland. It is acknowledged that the field is changing rapidly, and regular revisions in the coming months are pre-planned as evidence is increasing. Methods: Consensus guidelines for best practice were established by a multidisciplinary group of Swiss pediatric clinicians with expertise in intensive care, immunology/rheumatology, infectious diseases, hematology, and cardiology. Subsequent to literature review, four working groups established draft recommendations which were subsequently adapted in a modified Delphi process. Recommendations had to reach >80% agreement for acceptance. Results: The group achieved agreement on 26 recommendations, which specify diagnostic approaches and interventions across anti-inflammatory, anti-infectious, and support therapies, and follow-up for children with suspected PIMS-TS. A management algorithm was derived to guide treatment depending on the phenotype of presentation, categorized into PIMS-TS with (a) shock, (b) Kawasaki-disease like, and (c) undifferentiated inflammatory presentation. Conclusion: Available literature on PIMS-TS is limited to retrospective or prospective observational studies. Informed by these cohort studies and indirect evidence from other inflammatory conditions in children and adults, as well as guidelines from international health authorities, the Swiss PIMS-TS recommendations represent best practice guidelines based on currently available knowledge to standardize treatment of children with suspected PIMS-TS. Given the absence of high-grade evidence, regular updates of the recommendations will be warranted, and participation of patients in trials should be encouraged.
Keywords
COVID-19, Kawasaki disease, MIS-C, child, multisystem inflammatory syndrome, pediatric inflammatory multisystem syndrome, septic shock
Pubmed
Web of science
Open Access
Yes
Create date
18/06/2021 18:01
Last modification date
29/06/2021 6:35
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