Sex and gender differences in anticancer treatment toxicity - a call for revisiting drug dosing in oncology.

Details

Serval ID
serval:BIB_1999CFBDFACD
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Sex and gender differences in anticancer treatment toxicity - a call for revisiting drug dosing in oncology.
Journal
Endocrinology
Author(s)
Özdemir B.C., Gerard C.L., Espinosa da Silva C.
ISSN
1945-7170 (Electronic)
ISSN-L
0013-7227
Publication state
Published
Issued date
02/05/2022
Peer-reviewed
Oui
Volume
163
Number
6
Pages
bqac058
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
The practice of oncology has dramatically changed in the last decade with the introduction of molecular tumor profiling into routine tumor diagnostics and the extraordinary progress in immunotherapies. However, there remains an unmet need to explore personalized dosing strategies that take into account the patient's sex to optimize the balance between efficacy and toxicity for each individual patient. In this mini-review, we summarize the evidence on sex differences in toxicity of anticancer therapies and present data on dose reduction and dose discontinuation rates for selected chemotherapies and targeted therapies. Finally, we propose the investigation of body composition (specifically fat free muscle mass) as a viable approach for personalized treatment dosage.
Keywords
body composition, fat free muscle mass, gender differences, sex differences, targeted therapies
Pubmed
Open Access
Yes
Create date
17/05/2022 12:33
Last modification date
12/11/2022 6:37
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