Time trends in the treatment of acute myocardial infarction in Switzerland from 1986 to 1993: do they reflect the advances in scientific evidence from clinical trials?

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State: Public
Version: author
Serval ID
serval:BIB_19761AAF0DF0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Time trends in the treatment of acute myocardial infarction in Switzerland from 1986 to 1993: do they reflect the advances in scientific evidence from clinical trials?
Journal
Journal of Clinical Epidemiology
Author(s)
Bourquin M. G., Wietlisbach V., Rickenbach M., Perret F., Paccaud F.
ISSN
0895-4356 (Print)
ISSN-L
0895-4356 (Linking)
Publication state
Published
Issued date
09/1998
Peer-reviewed
Oui
Volume
51
Number
9
Pages
723-32
Language
english
Abstract
Three acute coronary care surveys (1986, 1990, and 1993) were conducted in the Swiss region of Vaud-Fribourg on all men aged 25 to 64 years hospitalized for a definite myocardial infarction (218, 224, and 167 cases). Nearly all patients received anticoagulants and nitrates. The proportion of patients treated increased significantly, between 1986 and 1990, for antiplatelet drugs (from 51% to 96%) and thrombolytics (from 9% to 44%) and, between 1990 and 1993, for beta-blockers (from 57% to 78%) and angiotensin-converting enzyme inhibitors (from 26% to 43%). The use of calcium antagonists and antiarrhythmics dropped over time. Coronary arteriography and angioplasty were increasingly performed (53% and 18% in 1993), although progressively postponed in-hospital stay. The observed trends reflect a rapid translation of clinical trials into medical practice. However the use of thrombolytics could be raised further by shortening the hospitalization delay (median: 3 hours in 1993) and door-to-needle time (median: 47 minutes) which remained stable over time.
Keywords
Adrenergic beta-Antagonists/*therapeutic use , Adult , Angiotensin-Converting Enzyme Inhibitors/*therapeutic use , Clinical Trials as Topic/*trends , Drug Utilization/trends , Fibrinolytic Agents/*therapeutic use , Follow-Up Studies , Humans , Male , Middle Aged , Myocardial Infarction/*drug therapy/mortality , Platelet Aggregation Inhibitors/*therapeutic use , Retrospective Studies , Survival Rate , Switzerland/epidemiology , Treatment Outcome
Pubmed
Web of science
Create date
29/01/2008 9:52
Last modification date
30/03/2020 7:08
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