Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response.

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Serval ID
serval:BIB_196C9DD1F044
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response.
Journal
Nature Communications
Author(s)
Antsiferova M., Huber M., Meyer M., Piwko-Czuchra A., Ramadan T., MacLeod A.S., Havran W.L., Dummer R., Hohl D., Werner S.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
2011
Volume
2
Pages
576
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: epublish
Abstract
Activin is an important orchestrator of wound repair, but its potential role in skin carcinogenesis has not been addressed. Here we show using different types of genetically modified mice that enhanced levels of activin in the skin promote skin tumour formation and their malignant progression through induction of a pro-tumourigenic microenvironment. This includes accumulation of tumour-promoting Langerhans cells and regulatory T cells in the epidermis. Furthermore, activin inhibits proliferation of tumour-suppressive epidermal γδ T cells, resulting in their progressive loss during tumour promotion. An increase in activin expression was also found in human cutaneous basal and squamous cell carcinomas when compared with control tissue. These findings highlight the parallels between wound healing and cancer, and suggest inhibition of activin action as a promising strategy for the treatment of cancers overexpressing this factor.
Pubmed
Web of science
Open Access
Yes
Create date
16/02/2012 14:36
Last modification date
20/08/2019 12:50
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