Artificial neural networks and pathologists recognize basal cell carcinomas based on different histological patterns.

Details

Serval ID
serval:BIB_19315E9B8A3B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Artificial neural networks and pathologists recognize basal cell carcinomas based on different histological patterns.
Journal
Modern pathology
Author(s)
Kimeswenger S., Tschandl P., Noack P., Hofmarcher M., Rumetshofer E., Kindermann H., Silye R., Hochreiter S., Kaltenbrunner M., Guenova E., Klambauer G., Hoetzenecker W.
ISSN
1530-0285 (Electronic)
ISSN-L
0893-3952
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Recent advances in artificial intelligence, particularly in the field of deep learning, have enabled researchers to create compelling algorithms for medical image analysis. Histological slides of basal cell carcinomas (BCCs), the most frequent skin tumor, are accessed by pathologists on a daily basis and are therefore well suited for automated prescreening by neural networks for the identification of cancerous regions and swift tumor classification.In this proof-of-concept study, we implemented an accurate and intuitively interpretable artificial neural network (ANN) for the detection of BCCs in histological whole-slide images (WSIs). Furthermore, we identified and compared differences in the diagnostic histological features and recognition patterns relevant for machine learning algorithms vs. expert pathologists.An attention-ANN was trained with WSIs of BCCs to identify tumor regions (n = 820). The diagnosis-relevant regions used by the ANN were compared to regions of interest for pathologists, detected by eye-tracking techniques.This ANN accurately identified BCC tumor regions on images of histologic slides (area under the ROC curve: 0.993, 95% CI: 0.990-0.995; sensitivity: 0.965, 95% CI: 0.951-0.979; specificity: 0.910, 95% CI: 0.859-0.960). The ANN implicitly calculated a weight matrix, indicating the regions of a histological image that are important for the prediction of the network. Interestingly, compared to pathologists' eye-tracking results, machine learning algorithms rely on significantly different recognition patterns for tumor identification (p < 10 <sup>-4</sup> ).To conclude, we found on the example of BCC WSIs, that histopathological images can be efficiently and interpretably analyzed by state-of-the-art machine learning techniques. Neural networks and machine learning algorithms can potentially enhance diagnostic precision in digital pathology and uncover hitherto unused classification patterns.
Keywords
Pathology and Forensic Medicine
Pubmed
Web of science
Create date
19/11/2020 15:59
Last modification date
02/12/2020 6:24
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