The type of K-ras mutation determines prognosis in colorectal cancer.

Details

Serval ID
serval:BIB_192E7021336A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The type of K-ras mutation determines prognosis in colorectal cancer.
Journal
American journal of surgery
Author(s)
Cerottini J.P., Caplin S., Saraga E., Givel J.C., Benhattar J.
ISSN
0002-9610
Publication state
Published
Issued date
1998
Peer-reviewed
Oui
Volume
175
Number
3
Pages
198-202
Language
english
Notes
Publication types: Journal Article - Publication Status: ppublish
Abstract
BACKGROUND: Mutations involving the oncogene K-ras in colorectal cancer may be related to tumor aggressiveness. However, the value of K-ras gene determination as a prognostic marker has not been clearly established. PATIENTS AND METHODS: The results from 98 patients recruited in a prospective study analyzing the effect of a K-ras mutation as a prognostic factor in colorectal cancer are reported. RESULTS: Disease-free (P = 0.02) and overall survival (P = 0.03) were significantly reduced for patients harboring a K-ras mutation. Two specific mutations demonstrated a significantly increased risk of disease recurrence, namely, 12-TGT (P = 0.04) and 13-GAC substitutions (P = 0.002). Patients with either of these substitutions had a 2-year disease-free survival rate of 37% compared with that of 67% for the group of patients harboring any other mutation type or a wild-type status (P = 0.01). CONCLUSIONS: The results herein presented suggest that K-ras acts as a prognostic factor in colorectal cancer and that this effect is probably related to a limited number of defined mutations.
Keywords
Adult, Aged, Aged, 80 and over, Colorectal Neoplasms, Disease-Free Survival, Female, Genes, ras, Humans, Male, Middle Aged, Mutation, Polymerase Chain Reaction, Polymorphism, Single-Stranded Conformational, Prognosis, Prospective Studies, Survival Analysis
Pubmed
Web of science
Create date
28/01/2008 8:56
Last modification date
20/08/2019 12:49
Usage data