Opponent appetitive-aversive neural processes underlie predictive learning of pain relief.

Details

Serval ID
serval:BIB_1927440C0550
Type
Article: article from journal or magazin.
Collection
Publications
Title
Opponent appetitive-aversive neural processes underlie predictive learning of pain relief.
Journal
Nature Neuroscience
Author(s)
Seymour B., O'Doherty J.P., Koltzenburg M., Wiech K., Frackowiak R., Friston K., Dolan R.
ISSN
1097-6256 (Print)
ISSN-L
1097-6256
Publication state
Published
Issued date
2005
Volume
8
Number
9
Pages
1234-1240
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Termination of a painful or unpleasant event can be rewarding. However, whether the brain treats relief in a similar way as it treats natural reward is unclear, and the neural processes that underlie its representation as a motivational goal remain poorly understood. We used fMRI (functional magnetic resonance imaging) to investigate how humans learn to generate expectations of pain relief. Using a pavlovian conditioning procedure, we show that subjects experiencing prolonged experimentally induced pain can be conditioned to predict pain relief. This proceeds in a manner consistent with contemporary reward-learning theory (average reward/loss reinforcement learning), reflected by neural activity in the amygdala and midbrain. Furthermore, these reward-like learning signals are mirrored by opposite aversion-like signals in lateral orbitofrontal cortex and anterior cingulate cortex. This dual coding has parallels to 'opponent process' theories in psychology and promotes a formal account of prediction and expectation during pain.
Keywords
Avoidance Learning/physiology, Behavior Therapy/methods, Brain/blood supply, Brain/physiopathology, Capsaicin/adverse effects, Conditioning (Psychology)/physiology, Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging/methods, Male, Models, Biological, Oxygen/blood, Pain/chemically induced, Pain/therapy, Pain Measurement/methods, Reward, Statistics, Nonparametric, Time Factors
Pubmed
Web of science
Create date
11/09/2011 18:17
Last modification date
20/08/2019 12:49
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