Metabolic connectivity as index of verbal working memory.

Details

Serval ID
serval:BIB_18C5AF7EF94F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Metabolic connectivity as index of verbal working memory.
Journal
Journal of Cerebral Blood Flow and Metabolism
Author(s)
Zou N., Chetelat G., Baydogan M.G., Li J., Fischer F.U., Titov D., Dukart J., Fellgiebel A., Schreckenberger M., Yakushev I.
ISSN
1559-7016 (Electronic)
ISSN-L
0271-678X
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
35
Number
7
Pages
1122-1126
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Positron emission tomography (PET) data are commonly analyzed in terms of regional intensity, while covariant information is not taken into account. Here, we searched for network correlates of healthy cognitive function in resting state PET data. PET with [(18)F]-fluorodeoxyglucose and a test of verbal working memory (WM) were administered to 35 young healthy adults. Metabolic connectivity was modeled at a group level using sparse inverse covariance estimation. Among 13 WM-relevant Brodmann areas (BAs), 6 appeared to be robustly connected. Connectivity within this network was significantly stronger in subjects with above-median WM performance. In respect to regional intensity, i.e., metabolism, no difference between groups was found. The results encourage examination of covariant patterns in FDG-PET data from non-neurodegenerative populations.
Pubmed
Web of science
Open Access
Yes
Create date
24/07/2015 17:00
Last modification date
20/08/2019 12:49
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