High number of CD56(bright) NK-cells and persistently low CD4+ T-cells in a hemophiliac HIV/HCV co-infected patient without opportunistic infections.

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State: Public
Version: author
Serval ID
serval:BIB_188B8B7EE244
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
High number of CD56(bright) NK-cells and persistently low CD4+ T-cells in a hemophiliac HIV/HCV co-infected patient without opportunistic infections.
Journal
Virology Journal
Author(s)
Fregni G., Maresca A.F., Jalbert V., Caignard A., Scott-Algara D., Cramer E.B., Rouveix E., Béné M.C. , Capron C.
ISSN
1743-422X (Electronic)
ISSN-L
1743-422X
Publication state
Published
Issued date
2013
Volume
10
Pages
33
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: epublish
Abstract
BACKGROUND: Both the human immunodeficiency virus (HIV) and hepatitis C virus (HCV), either alone or as coinfections, persist in their hosts by destroying and/or escaping immune defenses, with high morbidity as consequence. In some cases, however, a balance between infection and immunity is reached, leading to prolonged asymptomatic periods. We report a case of such an indolent co-infection, which could be explained by the development of a peculiar subset of Natural Killer (NK) cells.
RESULTS: Persistently high peripheral levels of CD56+ NK cells were observed in a peculiar hemophiliac HIV/HCV co-infected patient with low CD4 counts, almost undetectable HIV viral load and no opportunistic infections. Thorough analysis of NK-subsets allowed to identify a marked increase in the CD56bright/dim cell ratio and low numbers of CD16+/CD56- cells. These cells have high levels of natural cytotoxicity receptors but low NCR2 and CD69, and lack both CD57 and CD25 expression. The degranulation potential of NK-cells which correlates with target cytolysis was atypically mainly performed by CD56bright NK-cells, whereas no production of interferon γ (IFN-γ) was observed following NK activation by K562 cells.
CONCLUSIONS: These data suggest that the expansion and lytic capacity of the CD56bright NK subset may be involved in the protection of this « rare » HIV/HCV co-infected hemophiliac A patient from opportunistic infections and virus-related cancers despite very low CD4+ cell counts.
Keywords
Adult, Antigens, CD56/analysis, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes/immunology, Cell Degranulation, HIV Infections/complications, HIV Infections/immunology, Hemophilia A/complications, Hemophilia A/immunology, Hepatitis C/complications, Hepatitis C/immunology, Humans, Killer Cells, Natural/chemistry, Killer Cells, Natural/immunology, Male, Viral Load
Pubmed
Web of science
Open Access
Yes
Create date
07/03/2013 18:27
Last modification date
20/08/2019 12:49
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