Leanness and squamous cell oesophageal cancer

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Ressource 1Download: serval:BIB_18863.P001 (390.42 [Ko])
State: Public
Version: author
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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_18863
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Leanness and squamous cell oesophageal cancer
Journal
Annals of Oncology
Author(s)
Gallus S., La Vecchia C., Levi F., Simonato L., Dal Maso L., Franceschi S.
ISSN
0923-7534
Publication state
Published
Issued date
2001
Volume
12
Number
7
Pages
975-979
Language
english
Notes
licence nationale
Abstract
Background: Squamous cell oesophageal cancer is one of the few neoplasms inversely related to body mass index (BMI). However, it is not clear whether this is due to cancer-related weight loss or to other correlates of leanness.
Patients and methods: 395 incident, histologically confirmed cases of squamous cell oesophageal cancer and 1,066 controls, admitted for acute, non-neoplastic diseases, in Italy and Switzerland. Odds ratios (ORs) were derived from multiple logistic regression, including terms for education, tobacco, alcohol, non-alcohol energy, fruit and vegetable intake.
Results: The ORs for the lowest vs. the highest quartile of BMI in the year before diagnosis were 2.0 in men, 1.6 in women, and 1.9 (95% confidence interval: 1.3-2.9) in both sexes combined. The association with leanness was stronger in heavy smokers, but was not accounted for by smoking and drinking, nor by differences in diet. Weight change in the decade prior to diagnosis showed no linear association with risk. However, cases were not leaner than controls at age 30 (OR = 0.6 for the lowest BMI quartile) and 50 (OR = 1.1).
Conclusions: Leanness appears to be an indicator of squamous cell oesophageal carcinogenesis. However, low BMI in the distant past was unrelated to oesophageal cancer risk.
Keywords
Body Mass Index, Drinking, Oral Cancer, Oesophageal Cancer, Smoking, Body-Mass Index, Esophageal Cancer, Gastric Cardia, Alcohol Intake, Food Groups, Risk, Tobacco, Obesity, Adenocarcinomas, Association
Pubmed
Web of science
Open Access
Yes
Create date
19/11/2007 13:13
Last modification date
25/09/2019 7:08
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