Postnatal development of vascular resistance of the rabbit isolated perfused kidney: modulation by nitric oxide and angiotensin II.

Details

Serval ID
serval:BIB_1880FA76A252
Type
Article: article from journal or magazin.
Collection
Publications
Title
Postnatal development of vascular resistance of the rabbit isolated perfused kidney: modulation by nitric oxide and angiotensin II.
Journal
Pediatric Research
Author(s)
Simeoni U., Zhu B., Muller C., Judes C., Massfelder T., Geisert J., Helwig J.J.
ISSN
0031-3998 (Print)
ISSN-L
0031-3998
Publication state
Published
Issued date
1997
Peer-reviewed
Oui
Volume
42
Number
4
Pages
550-555
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
Studies were performed on isolated perfused kidneys (IPK) from postnatal developing rabbits to ask 1) whether the high renal vascular resistance (RVR) at birth involves intrinsic renal mechanisms, 2) whether nitric oxide (NO) release is involved in the modulation of renal vascular tone, and 3) whether NO modulates exogenous angiotensin II (AII)-induced vasoconstrictions. Kidneys isolated from 1-wk-old (during nephrogenesis), 3-wk-old (after nephrogenesis), and 6-wk-old rabbits were perfused in the presence of 10(-5) M indomethacin. RVR decreased with age from 12.7 +/- 0.6 at 1 wk to 10.1 +/- 0.5 mm Hg min g mL-1 at 6 wk. N omega-Nitro-L-arginine methyl ester (L-NAME, 10(-4) M) comparably increased RVR by about 30% at 1, 3, and 6 wk. The vasoconstrictions induced by 10(-8) M AII increased basal pressure from 28% at 1 wk to 78% at 6 wk and were potentiated by L-NAME by about 100%. In contrast, the vasoconstrictions induced by 10(-10) M AII decreased from 8% at 1 wk to 0% at 6 wk and were potentiated by L-NAME by about 250% at 1 and 3 wk. We conclude that during postnatal development: 1) RVR in IPK decreases in absence of AII and extrarenal influences, suggesting that high RVR at birth involves intrinsic mechanisms, 2) L-Arg/NO modulates basal tonus in developing IPK, and, 3) renal vasoconstrictor responses to exogenous AII are buffered by NO at early postnatal stages and follow an AII concentration-dependent developmental pattern. A specific neonatal high affinity AII/NO interaction disappearing after nephrogenesis completion precedes a low affinity AII/NO interaction, which progressively increases toward adult ages. These findings are in favor of a specific involvement of AII-NO interactions in the control of developing renal hemodynamics.
Keywords
Age Factors, Angiotensin II/pharmacology, Animals, Animals, Newborn, Enzyme Inhibitors/pharmacology, In Vitro Techniques, Kidney/blood supply, Kidney/drug effects, NG-Nitroarginine Methyl Ester/pharmacology, Nitric Oxide/pharmacology, Perfusion, Rabbits, Vascular Resistance/drug effects, Vascular Resistance/physiology, Vasoconstriction/drug effects, Vasoconstrictor Agents/pharmacology
Pubmed
Web of science
Open Access
Yes
Create date
22/02/2015 11:26
Last modification date
20/08/2019 12:49
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