Local deposition of calcium pyrophosphate crystals in evolution of knee osteoarthritis.

Details

Serval ID
serval:BIB_18750
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Local deposition of calcium pyrophosphate crystals in evolution of knee osteoarthritis.
Journal
Clinical Rheumatology
Author(s)
Reuge L., Van Linthoudt D., Gerster J.C.
ISSN
0770-3198 (Print)
ISSN-L
0770-3198
Publication state
Published
Issued date
2001
Volume
20
Number
6
Pages
428-431
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The aim of the study was to investigate the frequency of development of local calcium pyrophosphate (CPPD) crystal deposition in patients with knee OA initially found negative for these crystals, as well as to discover whether prognostic indicators for this subset of patients can be found. A clinical follow-up of records of outpatients with idiopathic knee OA was established. An anteroposterior plain radiography of the knee joints was made initially and at the end of the observation period. The follow-up period needed to be more than 1 year. Patients were divided into two groups. The first included patients with knee OA who did not develop intra-articular CPPD crystal deposition during the observation period (OA group). The second included those patients whose X-rays or synovial fluid (SF) analysis in the follow-up showed these crystal deposits to be present (OA + CPPD group). There were 59 patients (42 women, 17 men) who met the selection criteria. During the observation period (8.1 + 7.4 years in the OA group, 10.4 +/- 6 years in the OA + CPPD group), intra-articular CPPD deposits were observed in 15 patients (25%): 10 on the X-rays, eight in the SF and three in both examinations. Age at diagnosis of OA and incidence of obesity were similar in both groups. There was a trend (P = 0.21) towards men developing intra-articular CPPD crystal deposits more frequently than women. OA in only one knee joint was significantly more frequent in the group with CPPD (P<0.01). Of those with CPPD deposits 40% required surgery at the end of the observation period, compared to 27.2% of those without deposits (P = 0.27). The waiting period before knee surgery was shorter in the OA + CPPD group but the difference was not statistically significant. In conclusion, local CPPD crystal deposition was observed in 25% of cases during the evolution of knee OA. No predictive factors were found. OA of the knee could, per se, favour the development of CPPD deposits. The occurrence of intra-articular CPPD deposits seemed to be related to a more rapid and severe evolution of OA of the knee.
Keywords
Aged, Calcium Pyrophosphate, Chondrocalcinosis/epidemiology, Chondrocalcinosis/etiology, Crystallization, Female, Follow-Up Studies, Humans, Male, Middle Aged, Osteoarthritis, Knee/complications, Osteoarthritis, Knee/physiopathology, Prognosis, Retrospective Studies, Severity of Illness Index
Pubmed
Web of science
Create date
19/11/2007 12:12
Last modification date
20/08/2019 12:48
Usage data