Naturally acquired MAGE-A10- and SSX-2-specific CD8+ T cell responses in patients with hepatocellular carcinoma.

Details

Serval ID
serval:BIB_1874344F750A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Naturally acquired MAGE-A10- and SSX-2-specific CD8+ T cell responses in patients with hepatocellular carcinoma.
Journal
Journal of immunology
Author(s)
Bricard G., Bouzourene H., Martinet O., Rimoldi D., Halkic N., Gillet M., Chaubert P., Macdonald H.R., Romero P., Cerottini J.C., Speiser D.E.
ISSN
0022-1767
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
174
Number
3
Pages
1709-1716
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Immunotherapy is being proposed to treat patients with hepatocellular carcinoma (HCC). However, more detailed knowledge on tumor Ag expression and specific immune cells is required for the preparation of highly targeted vaccines. HCC express a variety of tumor-specific Ags, raising the question whether CTL specific for such Ags exist in HCC patients. Indeed, a recent study revealed CTLs specific for two cancer-testis (CT) Ags (MAGE-A1 and MAGE-A3) in tumor infiltrating lymphocytes of HCC patients. Here we assessed the presence of T cells specific for additional CT Ags: MAGE-A10, SSX-2, NY-ESO-1, and LAGE-1, which are naturally immunogenic as demonstrated in HLA-A2(+) melanoma patients. In two of six HLA-A2(+) HCC patients, we found that MAGE-A10- and/or SSX-2-specific CD8(+) T cells naturally responded to the disease, because they were enriched in tumor lesions but not in nontumoral liver. Isolated T cells specifically and strongly killed tumor cells in vitro, providing evidence that these CTL were selected in vivo for high avidity Ag recognition. Therefore, besides melanoma, HCC is the second solid human tumor with clear evidence for in vivo tumor recognition by T cells, providing the rational for specific immunotherapy, based on immunization with CT Ags such as MAGE-A10 and SSX-2.
Keywords
Aged, Aged, 80 and over, Antigen Presentation, Antigens, Neoplasm/biosynthesis, Antigens, Neoplasm/immunology, Antigens, Surface, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/metabolism, Carcinoma, Hepatocellular/immunology, Carcinoma, Hepatocellular/pathology, Cell Line, Tumor, Cytotoxicity Tests, Immunologic, Epitopes, T-Lymphocyte/immunology, Female, HLA-A2 Antigen/biosynthesis, Humans, Immunity, Innate, Leukocytes, Mononuclear/immunology, Leukocytes, Mononuclear/metabolism, Liver Neoplasms/immunology, Liver Neoplasms/pathology, Lymphocytes, Tumor-Infiltrating/immunology, Lymphocytes, Tumor-Infiltrating/metabolism, Male, Melanoma/immunology, Membrane Proteins/biosynthesis, Membrane Proteins/immunology, Neoplasm Proteins/biosynthesis, Neoplasm Proteins/immunology, Repressor Proteins/biosynthesis, Repressor Proteins/immunology
Pubmed
Web of science
Create date
28/01/2008 11:14
Last modification date
20/08/2019 12:48
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