Innate immunogenetics: a tool for exploring new frontiers of host defence.

Details

Serval ID
serval:BIB_1861A7E7704C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Innate immunogenetics: a tool for exploring new frontiers of host defence.
Journal
Lancet Infectious Diseases
Author(s)
Bochud P.Y., Bochud M., Telenti A., Calandra T.
ISSN
1473-3099
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
7
Number
8
Pages
531-542
Language
english
Notes
Publication types: Journal Article
Abstract
The discovery of innate immune genes, such as those encoding Toll-like receptors (TLRs), nucleotide-binding oligomerisation domain-like receptors (NLRs), and related signal-transducing molecules, has led to a substantial improvement of our understanding of innate immunity. Recent immunogenetic studies have associated polymorphisms of the genes encoding TLRs, NLRs, and key signal-transducing molecules, such as interleukin-1 receptor-associated kinase 4 (IRAK4), with increased susceptibility to, or outcome of, infectious diseases. With the availability of high-throughput genotyping techniques, it is becoming increasingly evident that analyses of genetic polymorphisms of innate immune genes will further improve our knowledge of the host antimicrobial defence response and help in identifying individuals who are at increased risk of life-threatening infections. This is likely to open new perspectives for the development of diagnostic, predictive, and preventive management strategies to combat infectious diseases.
Keywords
Bacterial Infections, Genotype, Humans, Immunity, Innate, Immunogenetics, Polymorphism, Genetic, Signal Transduction
Pubmed
Web of science
Create date
25/01/2008 13:28
Last modification date
20/08/2019 12:48
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