Médicaments et grossesse : modifications pharmacocinétiques et place du suivi thérapeutique pharmacologique [Pharmacokinetic Alterations in Pregnancy and Use of Therapeutic Drug Monitoring].

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State: Public
Version: author
Serval ID
serval:BIB_18592A49D874
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Médicaments et grossesse : modifications pharmacocinétiques et place du suivi thérapeutique pharmacologique [Pharmacokinetic Alterations in Pregnancy and Use of Therapeutic Drug Monitoring].
Journal
Therapie
Author(s)
Panchaud A., Weisskopf E., Winterfeld U., Baud D., Guidi M., Eap C.B., Csajka C., Widmer N.
ISSN
0040-5957 (Print)
ISSN-L
0040-5957
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
69
Number
3
Pages
223-234
Language
french
Notes
Publication types: JOURNAL ARTICLEPublication Status: ppublish
Abstract
Following the thalidomide tragedy, pharmacological research in pregnant women focused primarily on drug safety for the unborn child and remains only limited regarding the efficacy and safety of treatment for the mother. Significant physiological changes during pregnancy may yet affect the pharmacokinetics of drugs and thus compromise its efficacy and/or safety. Therapeutic drug monitoring (TDM) would maximize the potential effectiveness of treatments, while minimizing the potential risk of toxicity for the mother and the fetus. At present, because of the lack of concentration-response relationship studies in pregnant women, TDM can rely only on individual assessment (based on an effective concentration before pregnancy) and remains reserved only to unexpected situations such as signs of toxicity or unexplained inefficiency.
Keywords
pregnancy, pharmacokinetics, therapeutic drug monitoring, treatment outcome, teratogen
Pubmed
Web of science
Create date
14/07/2014 7:50
Last modification date
23/03/2020 8:08
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