French cohort of the uranium processing workers: mortality pattern after 30-year follow-up

Details

Serval ID
serval:BIB_1853B6C6E3BD
Type
Article: article from journal or magazin.
Collection
Publications
Title
French cohort of the uranium processing workers: mortality pattern after 30-year follow-up
Journal
International Archives of Occupational and Environmental Health
Author(s)
Guseva Canu Irina, Cardis Elisabeth, Metz-Flamant Camille, Caër-Lorho Sylvaine, Auriol Bernard, Wild Pascal, Laurier Dominique, Tirmarche Margot
ISSN
1432-1246 (Electronic)
ISSN-L
0340-0131
Publication state
Published
Issued date
03/2010
Peer-reviewed
Oui
Volume
83
Number
3
Pages
301-308
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
To investigate mortality among nuclear workers with potential internal exposure to uranium.
The cohort included 2,709 workers employed at the AREVA NC Pierrelatte plant for at least 6 months (72,787 person-years). This plant processed uranium enrichment during the period 1960-1996 and chemical conversion since 1980. Mortality was compared to the national and regional mortality rates available for the period 1968-2005. For causes of death of interest with respect to occupational exposure, mortality trends according to occupational characteristics were assessed.
As expected, an important healthy worker effect (all causes SMR = 0.55 (95% CI: 0.50-0.61), n = 411; all cancers SMR = 0.70 (95% CI: 0.60-0.81), n = 193) was observed. Among cancer sites a priori related to uranium exposure, only mortality for lymphatic cancer was increased among potentially exposed workers (SMR = 1.49 (95% CI: 0.68-2.82); n = 9). An important increase in mortality from pleural cancer was observed (SMR = 2.85 (95% CI: 0.93-6.66), n = 5); none of the deceased workers were exposed to radiation whereas all handled asbestos.
In spite of limited statistical power, results show consistency with previous studies of nuclear workers potentially exposed to uranium. Further investigation based on more precise uranium exposure data should allow the estimation of uranium hazard effects among this cohort.

Keywords
Adult, Cohort Studies, France/epidemiology, Humans, Male, Mortality/trends, Neoplasms/classification, Neoplasms/epidemiology, Nuclear Power Plants, Occupational Exposure/adverse effects, Uranium/administration & dosage, Uranium/adverse effects, Young Adult
Pubmed
Web of science
Create date
12/09/2017 15:19
Last modification date
20/08/2019 12:48
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