Exercise Prior to Lower Extremity Peripheral Artery Disease Improves Endurance Capacity and Hindlimb Blood Flow by Inhibiting Muscle Inflammation.

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License: CC BY 4.0
Serval ID
serval:BIB_1843AE278154
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Exercise Prior to Lower Extremity Peripheral Artery Disease Improves Endurance Capacity and Hindlimb Blood Flow by Inhibiting Muscle Inflammation.
Journal
Frontiers in cardiovascular medicine
Author(s)
Pellegrin M., Bouzourène K., Mazzolai L.
ISSN
2297-055X (Print)
ISSN-L
2297-055X
Publication state
Published
Issued date
2021
Peer-reviewed
Oui
Volume
8
Pages
706491
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Lower extremity peripheral artery disease (PAD) is associated with functional decline. Physical exercise has been proven to be an effective therapeutic strategy for PAD; however the effect of exercise initiated before PAD remains unknown. Here, we investigated the preventive effects of exercise on endurance capacity, hindlimb perfusion, and on polarization profile of circulating monocytes and limb muscle macrophages. ApoE <sup>-/-</sup> mice were subjected to 5-week running wheel exercise or remained sedentary before induction of hindlimb ischemia. The two groups were thereafter kept sedentary. Exercised mice prior to PAD showed higher exhaustive treadmill running distance and time than sedentary mice. Preventive exercise also increased perfusion, arteriole density, and muscle regeneration in the ischemic hindlimb. Moreover, preventive exercise prevented ischemia-induced increased gene expression of pro-inflammatory M1 macrophages markers and cytokines in the ischemic muscle, while no changes were observed for anti-inflammatory M2 macrophage markers. Flow cytometry analysis showed that the proportion of circulating pro-inflammatory monocyte subtype decreased whereas that of anti-inflammatory monocytes increased with preventive exercise. Overall, we show that exercise initiated before PAD improves endurance performance and hindlimb perfusion in mice probably via inhibition of M1 macrophage polarization and inflammation in the ischemic muscle. Our study provides experimental evidence for a role of regular exercise in primary prevention of PAD.
Keywords
arteriogenesis, exercise, inflammation, lower extremity peripheral artery disease, monocyte/macrophage phenotype, prevention, regeneration, skeletal muscle
Pubmed
Web of science
Open Access
Yes
Create date
03/09/2021 18:59
Last modification date
08/01/2022 7:33
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