Determination of <sup>161</sup>Tb half-life by three measurement methods.

Details

Serval ID
serval:BIB_18420F4693BA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Determination of <sup>161</sup>Tb half-life by three measurement methods.
Journal
Applied radiation and isotopes
Author(s)
Durán M.T., Juget F., Nedjadi Y., Bochud F., Grundler P.V., Gracheva N., Müller C., Talip Z., van der Meulen N.P., Bailat C.
ISSN
1872-9800 (Electronic)
ISSN-L
0969-8043
Publication state
Published
Issued date
05/2020
Peer-reviewed
Oui
Volume
159
Pages
109085
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The radiolanthanide <sup>161</sup> Tb is being studied as an alternative to <sup>177</sup> Lu for targeted radionuclide tumor therapy. Both β <sup>-</sup> -particle emitters show similar chemical behavior and decay characteristics, but <sup>161</sup> Tb delivers additional conversion and Auger electron emissions that may enhance the therapeutic efficacy. In this study, the half-life of <sup>161</sup> Tb was determined by a combination of three independent measurement systems: reference ionization chamber (CIR, chambre d'ionization de référence), portable ionization chamber (TCIR) and a CeBr <sub>3</sub> γ-emission detector with digital electronics. The half-life determined for <sup>161</sup> Tb is 6.953(2) days, showing a significant improvement in the uncertainty, which is one order of magnitude lower, with a deviation of 0.91% from the last nuclear data reference value. The previous large uncertainty of the half-life had a direct impact on activity measurements. Now it is no more an obstacle to a primary standardization.
Keywords
(161)Tb, Digital electronics, Half-life, Ionization chamber, Standardization
Pubmed
Create date
25/04/2020 22:31
Last modification date
02/03/2021 7:26
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