Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends, 1991-2000

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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_182048CCAD71
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends, 1991-2000
Journal
Clinical Infectious Diseases
Author(s)
Marchetti  O., Bille  J., Fluckiger  U., Eggimann  P., Ruef  C., Garbino  J., Calandra  T., Glauser  M. P., Tauber  M. G., Pittet  D.
ISSN
1537-6591 (Electronic)
Publication state
Published
Issued date
02/2004
Volume
38
Number
3
Pages
311-20
Notes
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't --- Old month value: Feb 1
Abstract
Candida species are among the most common bloodstream pathogens in the United States, where the emergence of azole-resistant Candida glabrata and Candida krusei are major concerns. Recent comprehensive longitudinal data from Europe are lacking. We conducted a nationwide survey of candidemia during 1991-2000 in 17 university and university-affiliated hospitals representing 79% of all tertiary care hospital beds in Switzerland. The number of transplantations and bloodstream infections increased significantly (P<.001). A total of 1137 episodes of candidemia were observed: Candida species ranked seventh among etiologic agents (2.9% of all bloodstream isolates). The incidence of candidemia was stable over a 10-year period. C. albicans remained the predominant Candida species recovered (66%), followed by C. glabrata (15%). Candida tropicalis emerged (9%), the incidence of Candida parapsilosis decreased (1%), and recovery of C. krusei remained rare (2%). Fluconazole consumption increased significantly (P<.001). Despite increasing high-risk activities, the incidence of candidemia remained unchanged, and no shift to resistant species occurred.
Keywords
Antifungal Agents/therapeutic use Candidiasis/drug therapy/*epidemiology Cross Infection/drug therapy/*epidemiology/microbiology Data Collection Drug Resistance, Microbial Fluconazole/therapeutic use Fungemia/drug therapy/*epidemiology Hospitals, University Humans Longitudinal Studies Microbial Sensitivity Tests Switzerland/epidemiology United States/epidemiology
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 13:33
Last modification date
25/09/2019 6:08
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