Relation between tumor necrosis factor-alpha and granulocyte elastase-alpha 1-proteinase inhibitor complexes in the plasma of patients with cystic fibrosis

Details

Serval ID
serval:BIB_1816E94D4625
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Relation between tumor necrosis factor-alpha and granulocyte elastase-alpha 1-proteinase inhibitor complexes in the plasma of patients with cystic fibrosis
Journal
American Review of Respiratory Disease
Author(s)
Suter  S., Schaad  U. B., Roux-Lombard  P., Girardin  E., Grau  G., Dayer  J. M.
ISSN
1073-449X
0003-0805
Publication state
Published
Issued date
12/1989
Volume
140
Number
6
Pages
1640-4
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Abstract
Patients with cystic fibrosis suffer from a chronic, progressively destructive bronchitis characterized by colonization of the airways by Pseudomonas aeruginosa. Cell wall lipopolysaccharides from P. aeruginosa may stimulate secretion of cytokines such as tumor necrosis factor alpha (TNF alpha) by monocytes/macrophages. We found elevated levels of TNF alpha (150 +/- 60 pg/ml), interleukin-1 alpha (144 +/- 205 pg/ml), and interleukin-1 beta (62 +/- 100 pg/ml) in plasma from 25 patients with cystic fibrosis. In patients with less advanced disease, elevated plasma levels of TNF alpha correlated with high levels of complexes between neutrophil elastase and alpha 1-proteinase inhibitor, suggesting that TNF alpha may be a mediator of neutrophil degranulation. TNF alpha, by its chemotactic effect on neutrophils, may also contribute to the massive influx of neutrophils into and around the bronchial tree. Our findings raise the questions whether in patients with cystic fibrosis TNF alpha acts as cachectin and whether it mediates the anorexia that often results in weight loss.
Keywords
Adolescent Adult Child Cystic Fibrosis/*blood/immunology/pathology Humans Immunoglobulin G/analysis Interferon Type I/blood Interleukin-1/blood Serine Proteinase Inhibitors/*blood *Serpins Tumor Necrosis Factor-alpha/*analysis alpha 1-Antitrypsin/*analysis
Pubmed
Web of science
Create date
15/01/2008 14:28
Last modification date
20/08/2019 12:48
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