Guillain-Barré syndrome after SARS-CoV-2 infection in an international prospective cohort study.

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State: Public
Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_17FB2E1F35D1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Guillain-Barré syndrome after SARS-CoV-2 infection in an international prospective cohort study.
Journal
Brain
Author(s)
Luijten LWG, Leonhard S.E., van der Eijk A.A., Doets A.Y., Appeltshauser L., Arends S., Attarian S., Benedetti L., Briani C., Casasnovas C., Castellani F., Dardiotis E., Echaniz-Laguna A., Garssen MPJ, Harbo T., Huizinga R., Humm A.M., Jellema K., van der Kooi A.J., Kuitwaard K., Kuntzer T., Kusunoki S., Lascano A.M., Martinez-Hernandez E., Rinaldi S., Samijn JPA, Scheidegger O., Tsouni P., Vicino A., Visser L.H., Walgaard C., Wang Y., Wirtz P.W., Ripellino P., Jacobs B.C.
Working group(s)
IGOS consortium
Contributor(s)
Jacobs B.C., Hughes RAC, Cornblath D.R., Gorson K.C., Hartung H.P., Kusunoki S., van Doorn P.A., Willison H.J., van den Berg B., Verboon C., Roodbol J., Doets A.Y., Leonhard S.E., Luijten LWG, de Koning L.C., Mandarakas M., van Woerkom M., Arends S., Reisin R.C., Reddel S.W., Islam Z., Mohammad Q.D., van den Bergh P., Feasby T.E., Wang Y., Harbo T., Péréon Y., Lehmann H.C., Dardiotis E., Nobile-Orazio E., Shahrizaila N., Bateman K., Illa I., Querol L., Ripellino P., Hsieh S.T., Chavada G., Davidson A., Addington J.M., Andersen H., Antonini G., Ajroud-Driss S., Attarian S., Badrising U.A., Balducci C., Barroso F.A., Bella I.R., Benedetti L., Bertorini T.E., Bhavaraju-Sanka R., Brannagan T.H., Briani C., Bürmann J., Busby M., Butterworth S., Casasnovas C., Castellani F., Cavaletti G., Chao C.C., Chen S., Claeys K.G., Conti M.E., Cosgrove J.S., Dalakas M.C., Derejko M.A., Dimachkie M.M., de la Cour C.D., Echaniz-Laguna A., Eftimov F., Faber K.G., Fazio R., Fokke C., Fujioka T., Fulgenzi E.A., Galassi G., García-Sobrino T., Garssen MPJ, Gentile F., Gijsbers C.J., Gilchrist J.M., Job Gilhuis H., Goldstein J.M., Goyal N.A., Granit V., Grapperon A.M., Grisanti S., Gutiérrez-Gutiérrez G., Gutmann L., Hadden RDM, Holbech J.V., Holt JKL, Htut M., Humm A., Hundsberger T., Jellema K., Pascual I.J., Jimeno Montero M.C., Kaida K., Karafiath S., Katzberg H.D., Khoshnoodi M., Kiers L., Kimpinski K., Kleyweg R.P., Kokubun N., Kolb N., Kuitwaard K., Kuntzer T., Kuwabara S., Kuwahara M., Kwan J.Y., Ladha S.S., Lassen L.L., Lascano A.M., Lawson V., Pan E.L., Cejas L.L., Magot A., Manji H., Marfia G.A., Márquez-Infante C., Aguilar L.M., Hernandez E.M., Sanchez P.M., Mataluni G., Mattiazzi M.G., McDermott C.J., Meekins G.D., Miller JAL, Monges M.S., de la Tassa G.M., Nascimbene C., Nedkova-Hristova V., Nowak R.J., Osei-Bonsu M., Pardo J., Pascuzzi R.M., Pritchard J., Pulley M., Rinaldi S., Roberts R.C., Rojas-Marcos I., Rudnicki S.A., Sachs G.M., Samijn JPA, Santoro L., Scheidegger O., Schenone A., Schwindling L., Sedano Tous M.J., Sheikh K.A., Silvestri N.J., Sindrup S.H., Sommer C.L., Song Y., Stein B., Stino A.M., Tan C.Y., Tankisi H., Tsouni P., Twydell P.T., Van Damme P., van der Kooi A.J., van der Meulen W., van der Ree T.C., van Dijk G.W., van Koningsveld R., Varrato J.D., Vermeij F.H., Verschuuren JJGM, Vicino A., Visser L.H., Vytopil M., Waheed W., Walgaard C., Wirtz P.W., Xing C., Yamagishi Y., Zhou L., Zivkovic S.
ISSN
1460-2156 (Electronic)
ISSN-L
0006-8950
Publication state
Published
Issued date
16/12/2021
Peer-reviewed
Oui
Volume
144
Number
11
Pages
3392-3404
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
In the wake of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, an increasing number of patients with neurological disorders, including Guillain-Barré syndrome (GBS), have been reported following this infection. It remains unclear, however, if these cases are coincidental or not, as most publications were case reports or small regional retrospective cohort studies. The International GBS Outcome Study is an ongoing prospective observational cohort study enrolling patients with GBS within 2 weeks from onset of weakness. Data from patients included in this study, between 30 January 2020 and 30 May 2020, were used to investigate clinical and laboratory signs of a preceding or concurrent SARS-CoV-2 infection and to describe the associated clinical phenotype and disease course. Patients were classified according to the SARS-CoV-2 case definitions of the European Centre for Disease Prevention and Control and laboratory recommendations of the World Health Organization. Forty-nine patients with GBS were included, of whom eight (16%) had a confirmed and three (6%) a probable SARS-CoV-2 infection. Nine of these 11 patients had no serological evidence of other recent preceding infections associated with GBS, whereas two had serological evidence of a recent Campylobacter jejuni infection. Patients with a confirmed or probable SARS-CoV-2 infection frequently had a sensorimotor variant 8/11 (73%) and facial palsy 7/11 (64%). The eight patients who underwent electrophysiological examination all had a demyelinating subtype, which was more prevalent than the other patients included in the same time window [14/30 (47%), P = 0.012] as well as historical region and age-matched control subjects included in the International GBS Outcome Study before the pandemic [23/44 (52%), P = 0.016]. The median time from the onset of infection to neurological symptoms was 16 days (interquartile range 12-22). Patients with SARS-CoV-2 infection shared uniform neurological features, similar to those previously described in other post-viral GBS patients. The frequency (22%) of a preceding SARS-CoV-2 infection in our study population was higher than estimates of the contemporaneous background prevalence of SARS-CoV-2, which may be a result of recruitment bias during the pandemic, but could also indicate that GBS may rarely follow a recent SARS-CoV-2 infection. Consistent with previous studies, we found no increase in patient recruitment during the pandemic for our ongoing International GBS Outcome Study compared to previous years, making a strong relationship of GBS with SARS-CoV-2 unlikely. A case-control study is required to determine if there is a causative link or not.
Keywords
Adult, Aged, COVID-19/complications, Cohort Studies, Female, Guillain-Barre Syndrome/epidemiology, Guillain-Barre Syndrome/virology, Humans, Male, Middle Aged, Prospective Studies, SARS-CoV-2, COVID-19, Guillain-Barré, clinical phenotype, preceding infections, syndrome
Pubmed
Web of science
Open Access
Yes
Create date
04/10/2021 10:55
Last modification date
12/02/2025 7:40
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