The NLRP3 inflammasome in health and disease: the good, the bad and the ugly.

Details

Serval ID
serval:BIB_17DA3D016800
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The NLRP3 inflammasome in health and disease: the good, the bad and the ugly.
Journal
Clinical and Experimental Immunology
Author(s)
Menu P., Vince J.E.
ISSN
1365-2249 (Electronic)
ISSN-L
0009-9104
Publication state
Published
Issued date
2011
Volume
166
Number
1
Pages
1-15
Language
english
Abstract
While interleukin (IL)-1β plays an important role in combating the invading pathogen as part of the innate immune response, its dysregulation is responsible for a number of autoinflammatory disorders. Large IL-1β activating platforms, known as inflammasomes, can assemble in response to the detection of endogenous host and pathogen-associated danger molecules. Formation of these protein complexes results in the autocatalysis and activation of caspase-1, which processes precursor IL-1β into its secreted biologically active form. Inflammasome and IL-1β activity is required to efficiently control viral, bacterial and fungal pathogen infections. Conversely, excess IL-1β activity contributes to human disease, and its inhibition has proved therapeutically beneficial in the treatment of a spectrum of serious, yet relatively rare, heritable inflammasomopathies. Recently, inflammasome function has been implicated in more common human conditions, such as gout, type II diabetes and cancer. This raises the possibility that anti-IL-1 therapeutics may have broader applications than anticipated previously, and may be utilized across diverse disease states that are linked insidiously through unwanted or heightened inflammasome activity.
Keywords
Animals, Anti-Inflammatory Agents/pharmacology, Bacterial Infections/immunology, Bacterial Infections/microbiology, Carrier Proteins/genetics, Carrier Proteins/immunology, Caspase 1/genetics, Caspase 1/immunology, Diabetes Mellitus, Type 2/drug therapy, Diabetes Mellitus, Type 2/immunology, Enzyme Activation, Enzyme Precursors/genetics, Enzyme Precursors/immunology, Gene Expression Regulation, Gout/drug therapy, Gout/immunology, Hereditary Autoinflammatory Diseases/drug therapy, Hereditary Autoinflammatory Diseases/immunology, Humans, Immunity, Innate, Inflammasomes/genetics, Inflammasomes/immunology, Inflammation/drug therapy, Inflammation/immunology, Interleukin-1beta/genetics, Interleukin-1beta/immunology, Mice, Mice, Transgenic, Molecular Targeted Therapy/methods, Mycoses/immunology, Mycoses/microbiology, Neoplasms/drug therapy, Neoplasms/immunology, Signal Transduction/immunology, Virus Diseases/immunology, Virus Diseases/virology
Pubmed
Web of science
Open Access
Yes
Create date
26/10/2011 12:08
Last modification date
20/08/2019 12:47
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