Diagnostic moderne de l'infection tuberculeuse: mesure de l'interferon-gamma. [Specific interferon-gamma assays: a modern tool for tuberculosis diagnosis]

Details

Serval ID
serval:BIB_17CB1235A525
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Diagnostic moderne de l'infection tuberculeuse: mesure de l'interferon-gamma. [Specific interferon-gamma assays: a modern tool for tuberculosis diagnosis]
Journal
Revue Médicale Suisse
Author(s)
Luarti Ruiz  F., Audran  R., Harari  A., Spertini  F.
ISSN
1660-9379 (Print)
Publication state
Published
Issued date
04/2006
Volume
2
Number
62
Pages
1042, 1044-7
Notes
English Abstract
Journal Article
Review --- Old month value: Apr 19
Abstract
Compared with the tuberculin skin test, the antigen-specific interferon-gamma assays, using a combination of two antigens ESAT-6 and CFP-10, has higher specificity for the diagnosis of latent tuberculosis, better correlation with exposure to M. tuberculosis, no cross-reactivity due to BCG vaccination and less towards nontuberculous mycobacterial infection. Fewer false positive results in uninfected persons avoid the costs of unnecessary therapy and its possible side effects. In low endemic areas, interferon-y assays are useful in addition of diagnostic algorithm for individuals with suspected tuberculosis. Further studies are required to evaluate the utility of the interferon-gamma assays in specialised subgroups of patients (immunocompromised, young children, patients with extrapulmonary disease,...) and as a marker of disease activity.
Keywords
Humans Interferon Type II/*blood Tuberculosis/*blood/*diagnosis
Pubmed
Create date
25/01/2008 15:00
Last modification date
20/08/2019 12:47
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