Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus.

Details

Serval ID
serval:BIB_179F1128ACCA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus.
Journal
Nature genetics
Author(s)
Ansari M.A., Pedergnana V., L C Ip C., Magri A., Von Delft A., Bonsall D., Chaturvedi N., Bartha I., Smith D., Nicholson G., McVean G., Trebes A., Piazza P., Fellay J., Cooke G., Foster G.R., Hudson E., McLauchlan J., Simmonds P., Bowden R., Klenerman P., Barnes E., Spencer CCA
Working group(s)
STOP-HCV Consortium
Contributor(s)
Barnes E., Ball J., Brainard D., Burgess G., Cooke G., Dillon J., Foster G.R., Gore C., Guha N., Halford R., Herath C., Holmes C., Howe A., Hudson E., Irving W., Khakoo S., Klenerman P., Koletzki D., Martin N., Massetto B., Mbisa T., McHutchison J., McKeating J., McLauchlan J., Miners A., Murray A., Shaw P., Simmonds P., Spencer CCA, Targett-Adams P., Thomson E., Vickerman P., Zitzmann N.
ISSN
1546-1718 (Electronic)
ISSN-L
1061-4036
Publication state
Published
Issued date
05/2017
Peer-reviewed
Oui
Volume
49
Number
5
Pages
666-673
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Outcomes of hepatitis C virus (HCV) infection and treatment depend on viral and host genetic factors. Here we use human genome-wide genotyping arrays and new whole-genome HCV viral sequencing technologies to perform a systematic genome-to-genome study of 542 individuals who were chronically infected with HCV, predominantly genotype 3. We show that both alleles of genes encoding human leukocyte antigen molecules and genes encoding components of the interferon lambda innate immune system drive viral polymorphism. Additionally, we show that IFNL4 genotypes determine HCV viral load through a mechanism dependent on a specific amino acid residue in the HCV NS5A protein. These findings highlight the interplay between the innate immune system and the viral genome in HCV control.
Keywords
Adaptive Immunity/genetics, Alleles, Genetic Variation, Genome, Human/genetics, Genome, Viral/genetics, Genotype, HLA Antigens/genetics, Hepacivirus/genetics, Hepacivirus/physiology, Hepatitis C, Chronic/genetics, Hepatitis C, Chronic/virology, Host-Pathogen Interactions/genetics, Humans, Immunity, Innate/genetics, Interleukins/genetics, Logistic Models, Principal Component Analysis, Viral Load/genetics, Viral Nonstructural Proteins/genetics
Pubmed
Web of science
Create date
13/09/2020 13:39
Last modification date
14/09/2020 5:26
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