Peroxisome proliferator-activated receptor gamma and regulations by the ubiquitin-proteasome system in pancreatic cancer.

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Serval ID
serval:BIB_179B9AF9D8C3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Peroxisome proliferator-activated receptor gamma and regulations by the ubiquitin-proteasome system in pancreatic cancer.
Journal
Ppar Research
Author(s)
Stravodimou A., Mazzoccoli G., Voutsadakis I.A.
ISSN
1687-4765 (Electronic)
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
2012
Pages
367450
Language
english
Notes
Publication types: Journal Article WOS Document Type: Review
Abstract
Pancreatic cancer is one of the most lethal forms of human cancer. Although progress in oncology has improved outcomes in many forms of cancer, little progress has been made in pancreatic carcinoma and the prognosis of this malignancy remains grim. Several molecular abnormalities often present in pancreatic cancer have been defined and include mutations in K-ras, p53, p16, and DPC4 genes. Nuclear receptor Peroxisome Proliferator-Activated Receptor gamma (PPARγ) has a role in many carcinomas and has been found to be overexpressed in pancreatic cancer. It plays generally a tumor suppressor role antagonizing proteins promoting carcinogenesis such as NF-κB and TGFβ. Regulation of pathways involved in pancreatic carcinogenesis is effectuated by the Ubiquitin Proteasome System (UPS). This paper will examine PPARγ in pancreatic cancer, the regulation of this nuclear receptor by the UPS, and their relationship to other pathways important in pancreatic carcinogenesis.
Pubmed
Web of science
Open Access
Yes
Create date
26/10/2012 18:31
Last modification date
20/08/2019 12:47
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