New T-cell receptor gamma haplotypes in wild mice and evidence for limited Tcrg-V gene polymorphism

Details

Serval ID
serval:BIB_179002E0A170
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
New T-cell receptor gamma haplotypes in wild mice and evidence for limited Tcrg-V gene polymorphism
Journal
Immunogenetics
Author(s)
Roger  T., Pepin  L. F., Jouvin-Marche  E., Cazenave  P. A., Seman  M.
ISSN
0093-7711 (Print)
Publication state
Published
Issued date
1993
Volume
37
Number
3
Pages
161-9
Notes
Journal Article
Research Support, Non-U.S. Gov't
Abstract
Tcrg gene polymorphism was investigated by Southern blot analysis on a panel of laboratory and wild mouse strains using a set of probes which identify all known Tcrg-V and -C genes. Only three haplotypes are found in laboratory mice: gA, gB, and gC which are represented by BALB/c, AKR, and DBA/2 prototypes respectively. gA and gC haplotypes are the most frequent among laboratory mice whereas gB is poorly represented. Seven new haplotypes are described among 23 wild mice corresponding to four Mus musculus subspecies (Mus mus domesticus, castaneus, musculus, and molossinus). However, only a few new alleles of individual genes are observed. Tcrg-V genes located at the 5' end of the Tcrg locus (V7 and V4) appear to be nonpolymorphic whereas two Tcrg-V3, -V5, -V6, -C4 and three Tcrg-V1, -V2, -C1, -C2, and -C3 specific restriction fragment length polymorphisms are detected. These results indicate a relatively high degree of conservation of Tcrg genes as compared to other members of the immunoglogulin (Ig) gene family and might be related to the specifity and function of gamma delta T cells. Several of the new haplotypes described here result from point mutations in noncoding Tcrg-V or -C gene-flanking regions. Recombinations may have also participated in the evolution of the Tcrg locus. Finally, these new Tcrg haplotypes are unequally distributed among the four M. m. subspecies and support the idea that the gA and gC haplotypes found in laboratory mice are inherited from M. m. domesticus whereas gB might originate from asian subspecies (castaneus, musculus or molossinus).
Keywords
Animals Chromosome Mapping *Haplotypes Mice/*genetics/immunology Mice, Inbred Strains *Polymorphism, Genetic Receptors, Antigen, T-Cell, gamma-delta/*genetics Recombination, Genetic
Pubmed
Web of science
Create date
25/01/2008 13:35
Last modification date
20/08/2019 12:47
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