Nodular regenerative hyperplasia: a deleterious consequence of chemotherapy for colorectal liver metastases?

Details

Serval ID
serval:BIB_1789D57ADDCC
Type
Article: article from journal or magazin.
Collection
Publications
Title
Nodular regenerative hyperplasia: a deleterious consequence of chemotherapy for colorectal liver metastases?
Journal
Liver International : Official Journal of the International Association For the Study of the Liver
Author(s)
Hubert C., Sempoux C., Horsmans Y., Rahier J., Humblet Y., Machiels J.P., Ceratti A., Canon J.L., Gigot J.F.
ISSN
1478-3223 (Print)
ISSN-L
1478-3223
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
27
Number
7
Pages
938-943
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
AIMS: This report describes three patients suffering from nodular regenerative hyperplasia (NRH).
METHODS: These patients have received six, 16 and 20 cycles of neoadjuvant 5-fluorouracil and oxaliplatin-based chemotherapy before planned extended hepatectomy. Two patients underwent uneventful portal vein embolization to hypertrophy the future remnant liver.
RESULTS: At the end of chemotherapy, liver function tests deteriorated and portal hypertension appeared in two patients, including ascites, splenomegaly and oesophageal varices. Liver biopsy was performed through a percutaneous (two patients) or a transjugular approach (one patient) and allowed the diagnosis of NRH, which was considered to be a contraindication for major liver resection in all three patients, associated with extrahepatic disease progression in one patient. All patients died from neoplastic disease progression despite further chemotherapy at 6, 17 and 31 months following the diagnosis of NRH. One patient developed liver failure and ascites at the time of death.
CONCLUSIONS: Physicians should be aware of the potential occurrence and therapeutic impact of NRH in patients suffering from CRLM and treated by neoadjuvant 5FU-oxaliplatin-based chemotherapy before major liver surgery.
Keywords
Aged, Antineoplastic Combined Chemotherapy Protocols/adverse effects, Chemotherapy, Adjuvant/adverse effects, Colorectal Neoplasms/drug therapy, Colorectal Neoplasms/mortality, Disease Progression, Drug-Induced Liver Injury, Female, Fluorouracil/administration & dosage, Hepatectomy/contraindications, Humans, Hyperplasia, Liver/drug effects, Liver/pathology, Liver Diseases/diagnosis, Liver Diseases/mortality, Liver Function Tests, Liver Neoplasms/drug therapy, Liver Neoplasms/mortality, Liver Regeneration/drug effects, Male, Middle Aged, Organoplatinum Compounds/administration & dosage, Time Factors, Treatment Outcome
Pubmed
Web of science
Create date
20/10/2016 16:10
Last modification date
20/08/2019 12:47
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