Quetiapine dosage in bipolar disorder episodes and mixed states

Details

Serval ID
serval:BIB_1786896F200B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Quetiapine dosage in bipolar disorder episodes and mixed states
Journal
Progress in Neuro-psychopharmacology & Biological Psychiatry
Author(s)
Khazaal Y., Tapparel S., Chatton A., Rothen S., Preisig M., Zullino D.
ISSN
0278-5846
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
31
Number
3
Pages
727-730
Language
english
Notes
SAPHIRID:61543
Abstract
OBJECTIVE: Although the maximal quetiapine doses in the published studies were restricted to 800 mg/day, higher quetiapine doses are not unusual in clinical practice. The aim of the present study was to evaluate the effectiveness, tolerability and clinical reasons associated to the use of high dosage of quetiapine (>800 mg), when used under routine clinical conditions, in a sample of bipolar disorder and schizoaffective bipolar inpatients. METHODS: Charts of all bipolar and schizoaffective adult inpatients, who had received quetiapine for a mood episode between 1999 and 2005 were retrospectively reviewed. These charts also included the assessment of manic and depressive symptoms on admission and at discharge using the Beck-Rafaelsen Mania Scale (MAS) and the Montgomery Asberg depression rating scale (MADRS), respectively. RESULTS: Data of 50 patients were analyzed. The overall F in repeated measures ANOVA revealed a significant MAS scores reduction between admission and discharge. MAS scores reduction did not differ between the high and low quetiapine groups. Similarly, a significant MADRS reduction was found. Again, no differences between the high and the low dose group were found. Logistic regression analysis of the 50 patients revealed only mixed episodes predicted high quetiapine dosage. CONCLUSIONS: The present study confirms quetiapine efficiency and tolerability in the treatment of bipolar episodes, even in doses > to 800 mg and found a link between quetiapine doses and mixed episodes
Pubmed
Web of science
Create date
13/03/2008 8:39
Last modification date
20/08/2019 12:47
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