Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.

Elks, C.E.; Perry, J.R.; Sulem, P.; Chasman, D.I.; Franceschini, N.; He, C.; Lunetta, K.L.; Visser, J.A.; Byrne, E.M.; Cousminer, D.L.; Gudbjartsson, D.F.; Esko, T.; Feenstra, B.; Hottenga, J.J.; Koller, D.L.; Kutalik, Z.; Lin, P.; Mangino, M.; Marongiu, M.; McArdle, P.F.; Smith, A.V.; Stolk, L.; van Wingerden, S.H.; Zhao, J.H.; Albrecht, E.; Corre, T.; Ingelsson, E.; Hayward, C.; Magnusson, P.K.; Smith, E.N.; Ulivi, S.; Warrington, N.M.; Zgaga, L.; Alavere, H.; Amin, N.; Aspelund, T.; Bandinelli, S.; Barroso, I.; Berenson, G.S.; Bergmann, S.; Blackburn, H.; Boerwinkle, E.; Buring, J.E.; Busonero, F.; Campbell, H.; Chanock, S.J.; Chen, W.; Cornelis, M.C.; Couper, D.; Coviello, A.D.; d'Adamo, P.; de Faire, U.; de Geus, E.J.; Deloukas, P.; Döring, A.; Smith, G.D.; Easton, D.F.; Eiriksdottir, G.; Emilsson, V.; Eriksson, J.; Ferrucci, L.; Folsom, A.R.; Foroud, T.; Garcia, M.; Gasparini, P.; Geller, F.; Gieger, C.; Gudnason, V.; Gudnason, V.; Hall, P.; Hankinson, S.E.; Ferreli, L.; Heath, A.C.; Hernandez, D.G.; Hofman, A.; Hu, F.B.; Illig, T.; Järvelin, M.R.; Johnson, A.D.; Karasik, D.; Khaw, K.T.; Kiel, D.P.; Kilpeläinen, T.O.; Kolcic, I.; Kraft, P.; Launer, L.J.; Laven, J.S.; Li, S.; Liu, J.; Levy, D.; Martin, N.G.; McArdle, W.L.; Melbye, M.; Mooser, V.; Murray, J.C.; Murray, S.S.; Nalls, M.A.; Navarro, P.; Nelis, M.; Ness, A.R.; Northstone, K.; Oostra, B.A.; Peacock, M.; Palmer, L.J.; Palotie, A.; Paré, G.; Parker, A.N.; Pedersen, N.L.; Peltonen, L.; Pennell, C.E.; Pharoah, P.; Polasek, O.; Plump, A.S.; Pouta, A.; Porcu, E.; Rafnar, T.; Rice, J.P.; Ring, S.M.; Rivadeneira, F.; Rudan, I.; Sala, C.; Salomaa, V.; Sanna, S.; Schlessinger, D.; Schork, N.J.; Scuteri, A.; Segrè, A.V.; Shuldiner, A.R.; Soranzo, N.; Sovio, U.; Srinivasan, S.R.; Strachan, D.P.; Tammesoo, M.L.; Tikkanen, E.; Toniolo, D.; Tsui, K.; Tryggvadottir, L.; Tyrer, J.; Uda, M.; van Dam, R.M.; van Meurs, J.B.; Vollenweider, P.; Waeber, G.; Wareham, N.J.; Waterworth, D.M.; Weedon, M.N.; Wichmann, H.E.; Willemsen, G.; Wilson, J.F.; Wright, A.F.; Young, L.; Zhai, G.; Zhuang, W.V.; Bierut, L.J.; Boomsma, D.I.; Boyd, H.A.; Crisponi, L.; Demerath, E.W.; van Duijn, C.M.; Econs, M.J.; Harris, T.B.; Hunter, D.J.; Loos, R.J.; Metspalu, A.; Montgomery, G.W.; Ridker, P.M.; Spector, T.D.; Streeten, E.A.; Stefansson, K.; Thorsteinsdottir, U.; Uitterlinden, A.G.; Widen, E.; Murabito, J.M.; Ong, K.K.; Murray, A.

doi:10.1038/ng.714

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.

Details

Download: BIB_1764CFBA5790.P001.pdf (820.26 [Ko])
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Serval ID

serval:BIB_1764CFBA5790

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.

Journal

Nature Genetics

Author(s)

Elks C.E., Perry J.R., Sulem P., Chasman D.I., Franceschini N., He C., Lunetta K.L., Visser J.A., Byrne E.M., Cousminer D.L., Gudbjartsson D.F., Esko T., Feenstra B., Hottenga J.J., Koller D.L., Kutalik Z., Lin P., Mangino M., Marongiu M., McArdle P.F., Smith A.V., Stolk L., van Wingerden S.H., Zhao J.H., Albrecht E., Corre T., Ingelsson E., Hayward C., Magnusson P.K., Smith E.N., Ulivi S., Warrington N.M., Zgaga L., Alavere H., Amin N., Aspelund T., Bandinelli S., Barroso I., Berenson G.S., Bergmann S., Blackburn H., Boerwinkle E., Buring J.E., Busonero F., Campbell H., Chanock S.J., Chen W., Cornelis M.C., Couper D., Coviello A.D., d'Adamo P., de Faire U., de Geus E.J., Deloukas P., Döring A., Smith G.D., Easton D.F., Eiriksdottir G., Emilsson V., Eriksson J., Ferrucci L., Folsom A.R., Foroud T., Garcia M., Gasparini P., Geller F., Gieger C., Gudnason V., Gudnason V., Hall P., Hankinson S.E., Ferreli L., Heath A.C., Hernandez D.G., Hofman A., Hu F.B., Illig T., Järvelin M.R., Johnson A.D., Karasik D., Khaw K.T., Kiel D.P., Kilpeläinen T.O., Kolcic I., Kraft P., Launer L.J., Laven J.S., Li S., Liu J., Levy D., Martin N.G., McArdle W.L., Melbye M., Mooser V., Murray J.C., Murray S.S., Nalls M.A., Navarro P., Nelis M., Ness A.R., Northstone K., Oostra B.A., Peacock M., Palmer L.J., Palotie A., Paré G., Parker A.N., Pedersen N.L., Peltonen L., Pennell C.E., Pharoah P., Polasek O., Plump A.S., Pouta A., Porcu E., Rafnar T., Rice J.P., Ring S.M., Rivadeneira F., Rudan I., Sala C., Salomaa V., Sanna S., Schlessinger D., Schork N.J., Scuteri A., Segrè A.V., Shuldiner A.R., Soranzo N., Sovio U., Srinivasan S.R., Strachan D.P., Tammesoo M.L., Tikkanen E., Toniolo D., Tsui K., Tryggvadottir L., Tyrer J., Uda M., van Dam R.M., van Meurs J.B., Vollenweider P., Waeber G., Wareham N.J., Waterworth D.M., Weedon M.N., Wichmann H.E., Willemsen G., Wilson J.F., Wright A.F., Young L., Zhai G., Zhuang W.V., Bierut L.J., Boomsma D.I., Boyd H.A., Crisponi L., Demerath E.W., van Duijn C.M., Econs M.J., Harris T.B., Hunter D.J., Loos R.J., Metspalu A., Montgomery G.W., Ridker P.M., Spector T.D., Streeten E.A., Stefansson K., Thorsteinsdottir U., Uitterlinden A.G., Widen E., Murabito J.M., Ong K.K., Murray A.

Working group(s)

GIANT Consortium

ISSN

1546-1718 (Electronic)

ISSN-L

1061-4036

Publication state

Published

Issued date

2010

Peer-reviewed

Oui

Volume

Number

Pages

1077-1085

Language

english

Notes

Publication types: Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.

Abstract

To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10⁻⁶⁰) and 9q31.2 (P = 2.2 × 10⁻³³), we identified 30 new menarche loci (all P < 5 × 10⁻⁸) and found suggestive evidence for a further 10 loci (P < 1.9 × 10⁻⁶). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.

Keywords

Adolescent, Aging/physiology, Body Height/genetics, Body Size/genetics, Child, DNA Copy Number Variations/genetics, Female, Genetic Loci/genetics, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Inheritance Patterns/genetics, Menarche/genetics, Obesity/genetics, Polymorphism, Single Nucleotide/genetics, Quantitative Trait Loci/genetics, Reproducibility of Results, Time Factors , Colaus Study

URN

urn:nbn:ch:serval-BIB_1764CFBA57901

OAI-PMH

oai:serval.unil.ch:BIB_1764CFBA5790

DOI

10.1038/ng.714

Pubmed

21102462

Web of science

000284578800010

Create date

01/12/2010 10:12