Exchange transfusion for severe malaria

Details

Serval ID
serval:BIB_17643CF4FB4E
Type
Article: article from journal or magazin.
Collection
Publications
Title
Exchange transfusion for severe malaria
Journal
Infection
Author(s)
Alfandari S., Dixmier G., Guery B., Leroy O., Georges H., Beaucaire G.
ISSN
0300-8126 (Print)
ISSN-L
0300-8126
Publication state
Published
Issued date
2001
Volume
29
Number
2
Pages
96-7
Language
english
Notes
Alfandari, S
Dixmier, G
Guery, B
Leroy, O
Georges, H
Beaucaire, G
eng
Germany
Infection. 2001 Mar-Apr;29(2):96-7. doi: 10.1007/s15010-001-1040-y.
Abstract
BACKGROUND: Exchange transfusion (ET) is a controversial ancillary treatment of severe falciparum malaria. PATIENTS AND METHODS: We conducted a retrospective analysis of severe malaria treated in our institution. Nine cases of ET were identified between 1991 and 1998 and compared to 12 controls with similar parasitemia. RESULTS: Groups were similar at admission except for an increased age in the ET group (p < 0.02). All patients received iv quinine. Outcome was similar in both groups (two deaths in the ET group, three in the control group). However, in patients with parasitemia > 30%, the death rate was significantly lower in ET patients than in controls (0/4 vs 3/3, p < 0.029). CONCLUSION: Despite definitive data from controlled trials, we suggest that ET should be considered in severe malaria cases with very high parasitemia and severity criteria or worsening clinical condition despite adequate chemotherapy.
Keywords
Adult, Aged, *Exchange Transfusion, Whole Blood, Female, Humans, Malaria, Falciparum/mortality/pathology/*therapy, Male, Middle Aged, Parasitemia, Retrospective Studies, Severity of Illness Index, Treatment Outcome
Pubmed
Create date
29/04/2021 10:59
Last modification date
30/04/2021 6:38
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