Isopropanol and methylformate exposure in a foundry: exposure data and neurobehavioural measurements.

Details

Serval ID
serval:BIB_17502
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Isopropanol and methylformate exposure in a foundry: exposure data and neurobehavioural measurements.
Journal
International Archives of Occupational and Environmental Health
Author(s)
Sethre T., Läubli T., Hangartner M., Berode M., Krueger H.
ISSN
0340-0131
Publication state
Published
Issued date
2000
Peer-reviewed
Oui
Volume
73
Number
8
Pages
528-536
Language
english
Notes
Publication types: Comparative Study
Abstract
OBJECTIVES: The aim of this study was to determine the dose-effect relationship between solvent exposure and acute neurobehavioural effects at the worksite. METHODS: In a balanced design, ten workers in a Swiss foundry were monitored for 15 days at ten different times during work. Urine samples were taken in the morning and at the time of examination, and personal exposure to isopropanol and methylformate was measured with active samplers. Neurobehavioural tests such as postural balance (bipedal, bipedal blind, monopedal), simple reaction time and digit span of the Neurobehavioural Evaluation System (NES2) and a combined memory and reaction-time test, the combi-test, were performed. A rating of well-being, and the last consumption of alcohol, caffeine, nicotine and medication were reported. RESULTS: Average environmental concentrations of isopropanol were at 44 ppm ( +/- 16 ppm), and at 36 ppm (+/-21 ppm) for methylformate. Maximum values of personal exposure to isopropanol reached barely the maximal allowable concentration (MAC) value (400 ppm); the methylformate personal exposure of three workers exceeded the MAC value (100 ppm). Urine concentrations of methanol were high (3.1 +/- 2.3 mg/l in the morning, 7.8 +/- 4.9 mg/l after exposure) compared with the results of other studies; concentrations of isopropanol were rather low (0.88 +/- 0.73 mg/l after exposure). CONCLUSIONS: Nevertheless, between personal exposure and biomonitoring, linear correlation was found. Methylformate exposure correlated with methanol and formic acid concentration in the urine, and isopropanol exposure with its concentration in the urine. With the neurobehavioural tests used, no solvent effect in relation to the dose could be determined.
Keywords
2-Propanol, Air Pollutants, Occupational, Environmental Monitoring, Formic Acid Esters, Formic Acids, Humans, Male, Maximum Allowable Concentration, Metallurgy, Methanol, Neurobehavioral Manifestations, Occupational Exposure, Solvents, Time Factors
Pubmed
Web of science
Create date
19/11/2007 12:11
Last modification date
20/08/2019 12:47
Usage data