Impact of Waddlia chondrophila infection on pregnancy in the mouse.

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Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_172D1E764896
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Impact of Waddlia chondrophila infection on pregnancy in the mouse.
Journal
New microbes and new infections
Author(s)
Baud D., Ammerdorffer A., Buffe Y., Vouga M., Greub G., Stojanov M.
ISSN
2052-2975 (Print)
ISSN-L
2052-2975
Publication state
Published
Issued date
01/2020
Peer-reviewed
Oui
Volume
33
Pages
100619
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The intracellular bacterium Waddlia chondrophila, which belongs to the Chlamydiales order, was found to be associated with miscarriage in humans. There is little to no knowledge regarding the mode of infection, impact on the neonate and pathophysiology of this emerging bacterium. We have previously shown that W. chondrophila induces a systemic infection, organ pathology and elicits T helper type 1-associated humoral immunity in a murine model of genital infection. In the present study, we took advantage of this model of infection to evaluate the impact of this bacterium on the mouse pregnancy. We used two routes of inoculation, vaginal and intrauterine, to introduce infection before and after mating. Our results show that genital infection by W. chondrophila did not have any significant impact on gestation length and maternal weight gain, nor on the number of offspring and their weight. This observation indicates that the mouse model of infection is not suitable to study the effect of W. chondrophila on pregnancy and alternative models of infection, including in vitro ones, should be used. Moreover, an indirect immunopathological mechanism activated by this bacterium should be further explored.
Keywords
Adverse pregnancy outcomes, Waddlia chondrophila, chlamydiales, genital model, mouse
Pubmed
Open Access
Yes
Create date
03/01/2020 22:32
Last modification date
15/01/2021 8:08
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